Manufacturing Supervisor, Downstream

Talentreq Partners Pte Ltd; Singapore; On-site; SGD 80,000 - 120,000; Full time

Job summary

A leading biopharmaceutical manufacturing company in Singapore is seeking an experienced biotechnologist to lead downstream operations. The role involves overseeing manufacturing processes, ensuring compliance with good practices, and managing team activities. Ideal candidates will have extensive experience in downstream manufacturing and proven supervisory skills.

Qualifications

• 8-12 years of relevant experience in biologics downstream manufacturing.
• 2 years supervisory experience in biotech/pharmaceutical manufacturing.
• Strong knowledge of cGMP documentation.

Responsibilities

• Lead and supervise the Biologics group ensuring smooth day-to-day operations.
• Oversee downstream manufacturing processes including chromatography and aseptic filling.
• Train junior staff members as a qualified trainer.

Skills

Leadership

Problem Solving

Prioritization

Education

Bachelor of Science

Tools

SAP

LIMS

Job description

Opportunity for an experienced biotechnologist with prior experience in leading downstream (DSP) teams for 2 to 3 years within the biologics production facility to join an established biopharmaceutical manufacturing in West of Singapore. You will oversee downstream manufacturing processes including large-scale chromatography, viral inactivation, and aseptic filling of bulk drug substances.

Role:

• Provide leadership, support, management, guidance and supervision for the Biologics group to ensure that all day-to-day activities of operations run smoothly and seamlessly.
• Assure that all performance metrics, workload deliverables are completed in alignment with the sites business model.
• Build and maintain collaborative relationships with other team members within the site and departments.
• Responsible for supporting Cell Culture, Central Services and Purification areas.
• Performs general to complex duties in assigned area within the Biologics Production facility.
• Complies with safety requirements, current Good Manufacturing Practices, and Standard Operating Procedures.
• Organize daily and weekly shift activities and direct junior personnel in execution of daily and weekly tasks.
• Operates equipment including Media Preparation, Buffer Preparation and Glass Wash/Autoclaves, bioreactors, inoculum transfers, filtration and chromatography equipment.
• Performs set-up and sterilization of components and process equipment, monitors and adjusts equipment operation
• Coordinates process sampling and routine measurements
• Ensures that data is recorded, activities logged, and processes monitored appropriately.
• Interfaces with automated production systems and controls.
• Reviews records for completeness and accuracy.
• Authors or revises standard operating procedures.
• Coordinates activities in the startup and validation of new equipment or new areas.
• Trains junior members as a qualified/certified trainer.
• Communicates all events/issues with appropriate individuals.
• Initiates or implements changes of both physical and written procedures.

Requirements:

• Bachelor of Sciencewith at least 8 to 12 years of relevant experience, especially in the area of biologics downstream manufacturing
• Must have at least 2 solid years of supervisory experience in Biotechnology/Pharmaceutical manufacturing downstream area
• Strong working knowledge of Microsoft and other software packages (SAP, LIMS)
• Experience with cGMP documentation and record maintenance
• Strong problem solving and prioritization skills
• Proficient in core and related work processes, and able to implement improvements to work processes.
• Knowledge of complex technical issues and manufacturing experience in a biopharmaceutical / pharmaceutical or similar environment.
• Shift work is required.

Interested applicants, please submit your profile to [e-mail] for review. We will be in touch for initial discussion upon being shortlisted

EA Licence: 17S8795 | EAP: R1108333