Senior Scientist, TCR-T Cell Therapy

NEOCYTOGEN THERAPEUTICS PTE. LTD.; Singapore; On-site; USD 70,000 - 110,000; Full time

Job summary

An innovative cell therapy company is seeking a passionate Scientist to lead TCR-T cell therapy programs targeting solid tumors. This role offers the chance to work with cutting-edge technologies in a collaborative environment, contributing to groundbreaking research that aims to revolutionize cancer treatment. The ideal candidate will have a strong background in immunology and hands-on experience in TCR-T therapy. Join a vibrant team dedicated to making a tangible impact on patients' lives through transformative science and enjoy opportunities for professional growth in a rapidly expanding field.

Benefits

Competitive salary

State-of-the-art research facilities

Inclusive work culture

Opportunities for professional growth

Qualifications

• 3+ years of hands-on experience in TCR-T therapy and T-cell engineering.
• Expertise in solid tumor biology and tumor antigen discovery.
• Strong data analysis skills using FlowJo and Python/R.

Responsibilities

• Design and execute experiments to optimize TCRs targeting solid tumor antigens.
• Collaborate with teams to advance preclinical candidates to clinical development.
• Mentor junior team members and prepare reports for stakeholders.

Skills

TCR-T therapy

T-cell engineering

cancer immunotherapy development

data analysis (FlowJo, GraphPad Prism, Python/R)

communication skills

Education

PhD in Immunology

PhD in Molecular Biology

PhD in Cell Biology

Tools

TCR cloning/engineering

lentiviral/retroviral transduction

T-cell functional assays

flow cytometry

in vivo tumor models

Job description

Neocytogen therapeutics is a pioneering cell therapy company based in Singapore, dedicated to developing breakthrough immunotherapies to combat cancer. Our mission is to revolutionize the treatment of solid tumors through innovative CAR-NK/TCR-T therapies. Leveraging cutting-edge technologies and a collaborative approach, we aim to deliver transformative solutions for patients worldwide.

The Role:
We are seeking a highly motivated and experienced Scientist to lead and advance our TCR-T cell therapy programs targeting solid tumors. The ideal candidate will have a strong background in immunology, molecular biology, or cell engineering, with a focus on developing TCR-based therapies. This role offers the opportunity to work in a dynamic, interdisciplinary team and contribute to groundbreaking research with real-world clinical impact.

Key Responsibilities:

· Design and execute experiments to discover, optimize, and validate TCRs targeting solid tumor antigens.

· Develop and optimize in vitro and in vivo models to evaluate TCR-T cell efficacy, safety, and persistence.

· Collaborate with cross-functional teams (bioinformatics, translational research, manufacturing) to advance preclinical candidates to clinical development.

· Analyze and interpret complex datasets to guide decision-making and troubleshoot technical challenges.

· Stay updated on the latest advancements in TCR-T therapy, tumor immunology, and solid tumor biology.

· Prepare technical reports, manuscripts, and presentations for internal and external stakeholders.

· Mentor junior team members and foster a culture of scientific excellence.

Qualifications:

· PhD in Immunology, Molecular Biology, Cell Biology, or a related field (postdoctoral or industry experience preferred).

· 3+ years of hands-on experience in TCR-T therapy, T-cell engineering, or cancer immunotherapy development, preferably in an industry or translational research setting.

· Expertise in solid tumor biology, tumor antigen discovery, and tumor microenvironment interactions.

· Proficiency in techniques such as TCR cloning/engineering, lentiviral/retroviral transduction, T-cell functional assays (cytotoxicity, cytokine release), flow cytometry, and in vivo tumor models.

· Strong data analysis skills (e.g., FlowJo, GraphPad Prism, Python/R).

· Excellent communication skills and ability to thrive in a fast-paced, collaborative environment.

· Experience with GMP/GLP standards or IND-enabling studies is a plus.

What We Offer:

· Competitive salary and benefits package.

· State-of-the-art research facilities and resources.

· A vibrant, inclusive, and mission-driven work culture.

· Opportunities for professional growth and leadership in a rapidly expanding field.

· The chance to make a tangible impact on patients’ lives through innovative science.

Location: Singapore

Apply now by submitting a CV, a cover letter outlining your research achievements and interest in TCR-T therapy, and contact details of 2-3 references to [e-mail]

We regret that only shortlisted candidates will be contacted.