Drug Substance MSAT Scientist

WuXi XDC; Singapore; On-site; SGD 80,000 - 110,000; Full time

Job summary

WuXi XDC in Singapore is seeking a hands-on professional to support mammalian cell culture operations, including cell expansion, bank establishment, shake flasks, and small bioreactors.

You will collaborate with PD and manufacturing teams, troubleshoot process deviations, maintain GDP-compliant documentation, draft SOPs, and ensure laboratory readiness through effective inventory and equipment upkeep.

Qualifications

• Bachelor’s degree or higher in life sciences or engineering, such as chemical engineering, bioengineering, biology, or pharmacy.
• With min 3 years of relevant hands-on experience in mammalian cell culture, aseptic operations, and bioreactor operation
• Strong communication, teamwork, logical thinking, and execution skills, with the ability to work under pressure.
• Familiarity with GMP requirements and documentation practices
• Excellent English proficiency in reading, writing, and speaking, with strong meeting organization and document writing skills.
• Strong sense of responsibility, willingness and ability to learn, teamwork spirit, and a positive attitude.

Responsibilities

• Cell culture theory and hands-on mammalian culture, including expansion, banks, shake flasks, and small bioreactors.
• Operate and maintain small-scale bioreactors using DeltaV and related equipment (Vi-cell, Cedex, BGA, Osmometer).
• Perform aseptic cell culture activities: media prep, inoculation, passaging, sampling, and cell bank handling in BSC.
• Collaborate with PD and manufacturing teams to ensure successful tech transfer.
• Lead and support troubleshooting investigations related to cell culture performance, process deviations, and equipment issues.
• Assist in laboratory management activities: equipment maintenance, inventory management, ensuring readiness.
• Maintain accurate and compliant GDP documentation.
• Draft, review, and update SOPs, RA, technical documents, and related records.
• Assist in conjugation projects as required.
• Perform other duties as assigned by supervisor.

Skills

Mammalian cell culture

Bioreactor operation

Aseptic techniques

GDP documentation

GMP compliance

Education

Bachelor’s degree or higher in life sciences or engineering

Tools

DeltaV

Vi-cell

Cedex

BGA

Osmometer

Job description

• Possess a solid understanding of cell culture theory and hands‑on experience in mammalian cell culture processes, including cell expansion, cell bank establishment, shake flask cultivation, and 3–15 L bioreactor operations
• Proficient in operating and maintaining small‑scale bioreactors using Delta V and related analytical equipment including Vi‑cell, Cedex, BGA and Osmometer
• Perform aseptic cell culture activities, including media preparation, inoculation, passaging, sampling, and cell bank handling within BSC
• Collaborate with PD and manufacturing teams to ensure successful tech transfer
• Lead and support troubleshooting investigations related to cell culture performance, process deviations, and equipment issues
• Assist in laboratory management activities, including equipment maintenance, inventory management, and ensuring laboratory readiness.
• Maintain accurate and compliant documentation in accordance with GDP and internal quality requirements.
• Draft, review, and update SOP, RA, technical documents, and related records.
• Assist in conjugation projects as required.
• Perform other duties and responsibilities as assigned by the supervisor.

Requirements

• Bachelor’s degree or higher in life sciences or engineering, such as chemical engineering, bioengineering, biology, or pharmacy.
• With min 3 years of relevant hands‑on experience in mammalian cell culture, aseptic operations, and bioreactor operation
• Strong communication, teamwork, logical thinking, and execution skills, with the ability to work under pressure.
• Familiarity with GMP requirements and documentation practices
• Excellent English proficiency in reading, writing, and speaking, with strong meeting organization and document writing skills.
• Strong sense of responsibility, willingness and ability to learn, teamwork spirit, and a positive attitude.