Research assistant in Tranlational Pharmacokinetics and Pharmacodynamics

Uppsala Universitet; Uppsala kommun; On-site; SEK 312,480 - 390,600; Full time

Job summary

Uppsala University, Department of Pharmacy in Uppsala is seeking a Research assistant to investigate biomarkers of chemotherapy-induced peripheral neuropathy (CIPN) using serum neurofilament light chain.

The project integrates pharmacokinetic-pharmacodynamic modeling to relate drug exposure in plasma and CIPN sites to serum biomarkers.

Qualifications

• Master's degree in pharmaceutical, medical, engineering/natural science or a related field.
• Experience in animal studies related to chemotherapy-induced peripheral neuropathy, UPLC-MS/MS drug bioanalysis, NfL bioanalysis, and PK/PD modeling/simulation.

Responsibilities

• Investigate biomarkers of CIPN with a focus on serum neurofilament light chain and barriers of the CNS and PNS.
• Use data to develop PK/PD models translating exposure to CIPN biomarkers.
• Work with chemotherapeutic agents including microtubule targeting drugs and antibody-drug conjugates.

Skills

Scientific writing

Teamwork

English language

Education

Master's degree in pharmaceutical/related field

Tools

UPLC-MS/MS

PK/PD modeling

Job description

Research assistant in Tranlational Pharmacokinetics and Pharmacodynamics

Uppsala University, Department of Pharmacy

The Department of Pharmacy at Uppsala University has an interdisciplinary environment at the center of the pharmaceutical arena. With frontline research, first-rate education and extensive collaborations we constitute a driving force in the development of our academic field. In this inspiring environment our rich diversity of research groups, several of international prominence, develop and conduct work of great scientific importance. Among our core competencies are computational modelling and simulations, PKPD, in vitro ADME models, advanced in vivo methods, biological medicines, as well as patient and societal aspects, from optimising the use of drugs in individuals to societal pharmaceutical policies. Together, we form a unique cluster of academic competencies within pharmaceutical science, playing a key role in shaping the future of pharmacy in both Sweden and globally.

Tasks: The project will involve investigation of biomarkers of chemotherapy-induced peripheral neuropathy (CIPN) with a focus on serum neurofilament light chain and the role of barriers of the central and peripheral nervous system in the development of CIPN. Data generated experimentally will be used for pharmacokinetic-pharmacodynamic modeling as a translation tool to characterize the relationship between the exposure of chemotherapeutic agents in plasma/CIPN sites and biomarkers in the serum. Chemotherapeutic agents will include several microtubule targeting drugs and antibody-drug conjugates.

Qualifications: The applicant must have a master's degree in pharmaceutical, medical, engineering/natural science or a related field. Applicants must have documented experience in animal studies related to chemotherapy-induced peripheral neuropathy, UPLC-MS/MS drug bioanalysis, NfL bioanalysis, and pharmacokinetic-pharmacodynamic modeling&simulation.

We place great emphasis on personal suitability as well as motivation and interest in improving the safety of anticancer drugs. The applicant must be able to express him/herself well, both orally and in writing, in English. Applicants must be able to work independently and in a group.

Merit: Understanding of the structure and function of barriers of the central and peripheral nervous system. Basic understanding of pharmacokinetics of antibody-drug conjugates. Hands-on experience in pharmacokinetic-pharmacodynamic data analysis and modeling. Interest in, and skill in, scientific writing in English is highly desirable.

About the employment The employment is a temporary position, 4 months. Scope of employment 100%. Starting date 1 September 2026 or as agreed. Placement: Uppsala

For further information about the position, please contact: Associate Professor Irena Loryan, [e-mail]

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Uppsala University is a broad research university with a strong international position. The ultimate goal is to conduct education and research of the highest quality and relevance to make a difference in society. Our most important asset is all of our 7,600 employees and 53,000 students who, with curiosity and commitment, make Uppsala University one of Sweden’s most exciting workplaces.

The position may be subject to security vetting. If security vetting is conducted, the applicant must pass the vetting process to be eligible for employment.