Postdoctoral studies in uncovering novel metabolic targets and differentiation inducing agents [...]

Karolinska Institutet; Solna kommun; On-site; SEK 290,000 - 350,000; Full time

Benefits offered by this job

Access to gym facilities

Opportunities for collaboration and exchange of knowledge

Job summary

Karolinska Institutet seeks a motivated postdoctoral researcher to study novel metabolic targets related to tumors. The role focuses on investigating MYC's impact on metabolic reprogramming and differentiation strategies in childhood tumors like neuroblastoma.

Applicants should possess a Ph.D. in Biomedical Science and proficiency in standard molecular and cell biology techniques. Working in a dynamic lab environment, candidates can expect opportunities for collaboration and professional growth.

Qualifications

• Experience in writing grant applications and supervising Bachelor and Master students.
• Fluency in English is required.

Responsibilities

• Investigate MYC's impact in metabolic reprogramming.
• Identify alternative strategies to induce differentiation in childhood tumors.
• Design experiments, perform research, analyze data, and present findings.

Skills

Advanced cell culture

Drug testing

Immunofluorescence

PCR

Western blot

Imaging techniques

Data analysis

Metabolic profiling assays

Sample preparation for Lipidomics

Proteomics

RNAseq

Omics analysis knowledge

Lentivirus transduction

In vivo studies in mice

Immunohistochemistry

Figure creation with Biorender

Education

Ph.D. in Biomedical Science

Job description

Postdoctoral studies in uncovering novel metabolic targets and differentiation inducing agents in tumors (scholarship)

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. Our key words are multidisciplinary, bridging, national and international collaborations.

Division

Marie Arsenian‑Henriksson's group conducts research on the MYC family of oncoproteins and network, to uncover their contribution to tumorigenesis, differentiation, metabolism, and apoptosis in different types of cancer. We are a multicultural and dynamic group with many national and international collaborators.

Duties

A highly motivated, skilled, and creative researcher is needed to join our team. The successful candidate will work within projects that aim to 1) investigate the impact of MYC in metabolic reprogramming to find novel metabolic proteins that could be used as a potential therapeutic target in childhood tumors such as neuroblastoma and medulloblastoma and 2) to identify alternative strategies involving MYC to induce differentiation of the most aggressive types of the childhood tumor neuroblastoma. The postdoctoral researcher is expected to have a leading role in experimental design, experimental performance, data analysis and representation, and presentation/publication of the results. The successful candidate should have experience in writing grant application and in supervising Bachelor and Master students.

Entry requirements

Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post‑doctoral education.

We are looking for an enthusiastic and driven person interested in our area of research and ready to explore new paths for cancer therapeutics.

In addition to the above mentioned requirements:

• The candidate should have a high degree of independence but with a collaborative mindset, work productively in a team, and contribute to a good social and work environment in the laboratory.
• The applicant should hold a Ph.D. degree in Biomedical Science and have a solid background in cancer biology.
• The candidate must be well familiar with standard molecular and cell biology techniques including:
  • Advanced cell culture, drug testing and immunofluorescence
  • Molecular biology techniques: PCR and Western blot
  • Imaging techniques and data analysis
  • Metabolic profiling assays
  • Sample preparation for Lipidomics, Proteomics and RNAseq
  • Basic knowledge on Omics analysis
  • Lentivirus transduction
  • In vivo studies in mice and immunohistochemistry of tumor samples
  • Making figure using Biorender
• Fluency in English is a requirement

Meritorious for the position:

• Previous experience in research on tumor metabolism, differentiation, and/or target identification is a prerequisite.
• Knowledge and experience in MYC, neuroblastoma or medulloblastoma fields is an advantage.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.