Postdoctoral studies in Molecular Immunology (scholarship)

Karolinska Institutet; Solna kommun; On-site; SEK 290,000 - 350,000; Full time

Benefits offered by this job

Access to modern gym facilities

Job summary

Karolinska Institutet is looking for a Postdoctoral Researcher in Molecular Immunology to contribute to research on immunodeficiency diseases. This role involves studying lymphocyte behavior and the development of innovative methods using advanced immunological technology.

The successful candidate will join the Westerberg lab in Solna and collaborate with international teams to understand the molecular basis of immunodeficiency diseases. A creative work environment, opportunities for professional growth, and benefits like access to gym facilities are offered.

Qualifications

• PhD or equivalent degree in a relevant field.
• Experience with CRISPR/Cas and AAV gene editing.
• Knowledge in super-resolution imaging and 3D genome research.

Responsibilities

• Perform studies of immune cells from patient samples and models.
• Identify molecular and cellular alterations in lymphocytes.
• Implement workflows and adapt existing methods.

Job description

Postdoctoral studies in Molecular Immunology (scholarship)

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. Our key words are multidisciplinary, bridging, national and international collaborations.

Division

The research group of Dr Lisa Westerberg seeks a Postdoc in the field of Immunology to study immunodeficiency diseases and lymphoma. The Westerberg lab has a long track record in deciphering molecular mechanism for development of severe immunodeficiency diseases in children (https://ki.se/en/mtc/lisa-westerberg-group ). Ongoing research in the Westerberg lab is focused on understanding the molecular mechanisms for development of immunodeficiency diseases with high incidence of lymphoma. The Westerberg lab uses a multidisciplinary and collaborative approach, working closely with research groups at KI, Karolinska University Hospital, Science for Life Laboratory (SciLifeLab), and with international research groups. Patient samples are obtained from national and international collaborators.

Duties

As a Westerberg lab member, you will perform studies of immune cells from patient samples, patient derived cell lines, gene edited cell lines, and animal models to examine how lymphocytes are affected by monogenetic mutations. Knowledge in studies of mutations that affect the cell cytoskeleton in the cytoplasm and in the nucleus is an advantage. Knowledge in super-resolution imaging and 3D genome will also be of advantage. The project will be focused on identifying molecular and cellular alterations of patients’ lymphocytes and discovery of cytoplasm-nucleus signaling pathways. We aim to recruit an independent and motivated person who can set up and maintain workflows by implementing or adapting existing methods of the Westerberg lab.

As a Postdoc you will be part of a multidisciplinary and collaborative research team active within the fields of immunodeficiency disease, lymphocyte biology, and lymphoma. The Westerberg lab uses state of the art immunological technology including molecular biology tools such as CRISPR/Cas and AAV gene editing to generate patient mutations and insert biochemical tags, advanced flow cytometry and microscopy, Omics approaches, and usage of both patient samples and experimental models. These efforts aim to map key molecular events that contribute to the disease pathogenesis of immunodeficiencies and lymphoma and to drive the development of precision medicine.

Entry requirements

Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.