Postdoctoral in Pluripotent Stem Cell Models of Human Development

University of Gothenburg; Göteborgs kommun; On-site; SEK 540,000 - 660,000; Full time

Job summary

The University of Gothenburg seeks a post-doctoral fellow to join a European Research Council-funded lab focusing on single-cell profiling and pluripotent stem cell platforms for embryonic development and disease. Affiliated with the Institute of Biomedicine and the Sahlgrenska Center for Cancer Research, the role sits within a collaborative environment bridging basic biology and clinical science.

The successful candidate will establish proteomics and single-cell workflows to dissect

Qualifications

• Expertise in developmental biology, stem cells and/or single-cell profiling techniques
• Communication and team work skills
• Hands-on experience in chromatin immunoprecipitation, next-generation sequencing library preparation, and/or droplet-based single-cell profiling techniques
• Demonstrated skills in human pluripotent stem cell culture and differentiation, proteomics, fluorescence-activated cell sorting, flow cytometry data analysis, and/or computational analysis of next-generation sequencing data

Responsibilities

• Work in a cross-disciplinary team and establish proteomics and single-cell profiling analysis workflows to study developmental processes modelled in stem cell differentiation cultures
• Supervise junior colleagues and contribute to manuscript writing while presenting work regularly at group and department meetings
• Lead or contribute to training and teaching activities within the group as appropriate
• Engage in computational analysis of sequencing data and participate in project meetings to guide experimental design

Skills

Developmental biology

Stem cells

Single-cell profiling

Chromatin IP

NGS library prep

Proteomics

Flow cytometry

FACS

NGS data analysis

Job description

The University of Gothenburg tackles society’s challenges with diverse knowledge. 58 000 students and 6800 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Guibentif lab is looking to recruit a post-doctoral fellow. We are a European Research Council-funded lab, applying single-cell profiling towards establishing novel pluripotent stem cell-based platforms for the study of human embryonic development and disease.

We are affiliated to the University of Gothenburg (GU), one of the largest universities in Northern Europe. Given our affiliation to the Institute of Biomedicine and to the Sahlgrenska Center for Cancer Research, we are part of a supportive interdisciplinary environment, comprising basic developmental biologists as well as clinical scientists.

The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.

The Sahlgrenska Center for Cancer Research is a joint venture between the GU Faculty of Medicine and the Sahlgrenska University Hospital focused on cancer translational research.

The overall goal of this project is to bridge current in vitro models of human embryonic development with the latest progress in developmental hematopoiesis studied in vivo. This will lead to new platforms to study molecular mechanisms of embryonic development.

We harness single-cell genomics and advanced experimental models to determine to what extent in vitro stem cell systems mimic the variety of molecular programmes underlying the emergence of hematopoietic cells at multiple anatomical locations and timepoints in the developing embryo.

Duties

The selected candidate will be expected to work in a cross-disciplinary team, and to establish proteomics and single-cell profiling analysis workflows to dissect developmental processes modelled in stem cell differentiation cultures.

Therefore, we seek a candidate capable of working as part of a diverse team, with an interest in studying molecular drivers of mammalian embryonic development as well as prior experience in aseptic cell culture techniques and molecular biology. We seek a candidate eager to work with others, and to develop leadership and teaching skills by participating in the supervision of junior colleagues. The selected candidate will also be expected to contribute to manuscript writing and will be expected to present their work regularly at group and department meetings.

Prior hands-on experience in chromatin immunoprecipitation, next-generation sequencing library preparation, and/or droplet-based single-cell profiling techniques will be an advantage. Applicants having demonstrated skills in proteomics, fluorescence-activated cell sorting, flow cytometry data analysis, or computational skills in next-generation sequencing data analysis will also be considered.

Assessment criteria

1. Expertise in developmental biology, stem cells and/or single-cell profiling techniques
2. Communication and team work skills
3. Hands-on experience in chromatin immunoprecipitation, next-generation sequencing library preparation, and/or droplet-based single-cell profiling techniques
4. Demonstrated skills in human pluripotent stem cell culture and differentiation, proteomics, fluorescence-activated cell sorting, flow cytometry data analysis, and/or computational analysis of next-generation sequencing data

Employment

The employment is full time and temporary, two years with the possibility of one year's extension, with placement at the Institute of Biomedicine. First day of employment as agreed.

Contact information

Please contact: Carolina Guibentif, Researcher, [phone], [e-mail]

Applications must be received by: 2026-11-11