Postdoc in Cancer Genomics

SciLifeLab Group; Linköpings kommun; On-site; SEK 437,000 - 523,000; Full time

Job summary

The SciLifeLab Group at LiU Cantù Lab is seeking a postdoctoral researcher to investigate how Wnt signaling regulates cell fate and contributes to cancer heterogeneity. You will focus on context-dependent transcriptional responses using organoid cultures and single-cell analyses.

The role is full-time for three years with potential 6–12 months abroad and opportunities to initiate independent funding. Teaching may occur up to 20% of your time, and collaboration in an international, competitive

Qualifications

• PhD in molecular biology or related field.
• PhD from an institution other than LiU.
• Experience with advanced cell culture systems, e.g., organoids.
• Experience with transcription factor profiling and single-cell transcriptomics analyses.
• Computational skills in R and Python.
• Fluency in English.
• Willingness to teach up to 20% of working hours.

Responsibilities

• Undertake research on how Wnt signaling regulates cell fate and cancer heterogeneity.
• Teach up to 20% of working hours.
• Collaborate in an international research group.
• Disseminate findings through publications and presentations.

Skills

Cell culture

Organoids

RT-qPCR

Western Blot

DNA cloning

Transcription factor profiling

Single-cell transcriptomics

Fluent English

Microscopy

Immunohistochemistry

Cell culture differentiation protocols

R

Python

Education

PhD in molecular biology

Tools

R

Python

Microscopy

Immunohistochemistry

Job description

Job reference

Ref BKV-2026-00796

Work assignments

Your work will entail the investigation of how Wnt signaling, a cell-to-cell communication pathway conserved across the animal kingdom, acts as regulator of cell fate. While the mechanisms of canonical Wnt pathway have been extensively studied, it is yet not understood how nuclear protein \u03b2-catenin can drive the wide arrays of transcriptional responses depending on the context or developmental stage. You will focus on different cancer types that display a constitutively active Wnt pathway, and investigate how this pathway contributes to heterogenous cell behavior and ability to self-renew, differentiate and migrate.

As postdoc, you will principally carry out research. A certain amount of teaching may be part of your duties, up to a maximum of 20% of working hours.

Qualifications

To be qualified to take employment as postdoc, you must have been awarded a doctoral degree or have a foreign degree that is deemed to be equivalent to a doctoral degree. This degree must have been awarded at the latest by the point at which LiU makes its decision to employ you.

Your doctoral degree must have been awarded no more than three years before the application deadline for this position. If there are special grounds, applicants who were awarded their doctoral degree earlier may also be considered, for example due to medical internship or specialist medical training, or various types of statutory leave. You must hold a doctoral degree awarded by a higher education institution other than Linköping University.

We are looking for someone with a PhD in a subject related to molecular biology. Alternatively, you have gained essentially corresponding knowledge in another way.

Among the required qualification, the applicant will possess experience with advanced cell culture systems, such as organoids from various organs. In addition to basic molecular biology (RT-qPCR, Western Blot, DNA cloning), the candidate must have experience with transcription factors profiling and single-cell transcriptomics analyses, and computational skills (e.g., R and Python).

Meritorious will be considered experience in Microscopy-based imaging, Immunohistochemistry, and cell culture differentiation protocols.

You are a curiosity-drive person, fascinated by the complexity of biological systems and their ability to self-organize. You are also drawn to teaching and supervision of younger students, and to work in cooperation in an internationally-oriented, competitive research group. Fluency in spoken and written English is required for this position.

The workplace

The Cantù Lab is located at the Division of Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, at the Medical Faculty of LiU.

The Lab is also part of the Wallenberg Center for Molecular Medicine and the SciLifeLab.

If you wish to know more about our research, team, or professional values, please visit: https://liu.se/en/research/cantu-lab and https://www.scilifelab.se/researchers/claudio-cantu/

The employment

The position is a full-time, fixed-term appointment for three years.

Within the framework of the appointment, the postdoctoral researcher may spend 6–12 months at a higher education institution abroad, funded by the Foundation.

Before the third year of the appointment, the postdoctoral researcher may apply to the Foundation for an independent research grant of approximately SEK 500,000. The grant is intended for a researcher who has the ambition and, in the Foundation’s assessment, the ability to establish an independent research environment.

The starting date will be agreed upon, with commencement during 2027.

Salary and employment benefits

The position is funded by the Högbom-Cocozza Research Foundation and carries a salary of SEK 43,000 per month.

Union representatives

Information about union representatives, see Help for applicants.

Contact persons

Claudio Cantù, Professor, [e-mail]

Johanna Källming, HR-partner, [e-mail]

We welcome applicants with different backgrounds, experiences and perspectives – diversity enriches our work and helps us grow. Preserving everybody’s equal value, rights and opportunities is a natural part of who we are. Read more about our work with: Equal opportunities.