PhD: Spatial Proteomics for Mitochondrial Disease

Varbi Recruit; Solna kommun; On-site; SEK 312,000 - 357,000; Full time

Job summary

Karolinska Institutet in Solna invites applications for a Doctoral (PhD) student position in spatial proteomics of mitochondrial disease. The project combines spatial single-cell proteomics with a mouse model to build a multi-modal atlas and to map subcellular changes along a disease trajectory.

The role spans wet-lab work, imaging, and computational analysis in a highly collaborative, international setting, with English as working language.

Qualifications

• A master's degree in Molecular Biology, Biotechnology, Bioinformatics, or related field.
• Wet-lab skills in molecular biology methods.
• Experience with histology and (immuno)staining.
• Background in bioinformatics and/or image analysis.
• Programming skills in Python.
• GitHub repository with code contributions.
• Good interpersonal skills and ability to work in a team.

Responsibilities

• Build an OXPHOS-stratified, multi-modal atlas of the mouse model.
• Combine Deep Visual Proteomics with multiplexed imaging to study disease trajectory.
• Duties include wet-lab work, histology, imaging, image analysis, and bioinformatic data analysis.

Skills

Wet-lab skills

Bioinformatics & image analysis

Python programming

Mouse genetics / mouse models

Interdisciplinary collaboration

Education

Master's degree in Molecular Biology, Biotechnology, Bioinformatics, or related field

Tools

GitHub

Job description

Karolinska Institutet in Solna invites applications for a Doctoral (PhD) student position in spatial proteomics of mitochondrial disease. The project combines spatial single-cell proteomics with a mouse model to build a multi-modal atlas and to map subcellular changes along a disease trajectory.

The role spans wet-lab work, imaging, and computational analysis in a highly collaborative, international setting, with English as working language.