Downstream Process Specialist

Mpya Sci & Tech; Stockholms kommun; On-site; SEK 900,000 - 1,300,000; Full time

Job summary

Mpya Sci & Tech is seeking a scientist to develop, optimize, and troubleshoot purification processes for recombinant proteins and biologics. You will lead downstream development projects, improve yields and product quality, and work toward robust, scalable solutions for GMP manufacturing.

Ideal candidates have a PhD in a Life Science field, extensive experience with chromatography and filtration (UF/DF), and proven ability to work independently in a GMP-regulated environment, including

Qualifications

• Requires PhD or equivalent with strong background in Life Science
• Extensive hands-on experience in downstream development and protein purification
• Experience with chromatography and filtration, including UF/DF, in GMP environments

Responsibilities

• Develop, optimize and troubleshoot purification processes for recombinant proteins and other biological molecules.
• Plan and evaluate experiments; analyze results to improve yield and quality.
• Collaborate with specialists and CMOs/CDMOs; prepare scalable solutions for GMP manufacturing

Skills

Downstream process development

Protein purification

Chromatography

Filtration / UF-DF

GMP/regulatory environment

CMO/CDMO experience

Independent problem-solving

Swedish language

English language

Education

PhD in biotechnology/biochemistry/chemical engineering or related field

Tools

UF/DF

Filtration

Chromatography systems

Job description

Would you like to develop and improve purification processes for complex proteins and help develop future medicines?

At Mpya Sci & Tech, we are looking for someone with solid experience in downstream process development and protein purification. You have a strong technical background, enjoy solving complex problems and like finding new solutions when existing methods are not enough.

As a consultant at Mpya Sci & Tech, you will have the opportunity to use your expertise in development projects at pharmaceutical and biotech companies. Your assignments may range from early-stage process development to optimization and scale-up ahead of manufacturing.

About the role

You will develop, optimize and troubleshoot purification processes for recombinant proteins and other biological molecules. This may involve developing new purification strategies, improving yield and product quality, or solving challenges related to aggregation, adsorption, instability and product loss.

Your work will include:

• Developing and optimizing purification processes using chromatography and filtration.
• Improving protein purity, stability, activity and yield.
• Planning and evaluating experiments and analyzing results.
• Troubleshooting processes and making them more robust, with future scale-up and GMP manufacturing in mind.

You will work closely with other specialists and contribute your expertise to developing reliable and practical process solutions.

Who are we looking for?

We are looking for someone with:

• A relevant university degree in Life Science, preferably a PhD in biotechnology, biochemistry, chemical engineering or a related field.
• Several years of experience in downstream process development and protein purification.
• Hands-on experience with chromatography and filtration, such as ultrafiltration and diafiltration (UF/DF).
• Experience working in a GMP-regulated environment within the development or manufacturing of biological medicines.
• Experience working with CMOs/CDMOs in process development or manufacturing.
• The ability to drive development work independently, analyze results and solve complex technical problems.
• Excellent written and spoken in Swedish and English.

Experience in purifying challenging proteins and enzymes, scaling up processes and process validation is an advantage. Experience with regulatory documentation for biological medicines is also beneficial.

You are analytical, curious and solution-oriented. You enjoy solving technical challenges, take initiative and work well both independently and as part of a team.

Mpya Sci & Tech was founded by people who love science and technology, for people who share that passion. Many of us have backgrounds in industry and consulting, so we know how important it is to find the right match, have support throughout your assignment and work for an employer who listens.

At Mpya, you can be yourself. Our office feels like a shared living room, and our culture is built on curiosity, openness and respect.

Read more at www.mpyascitech.com.

Does this sound like a role for you? We look forward to hearing from you!