Senior Manager, Process Engineering

Vertex Pharmaceuticals Inc (US); Leiden; On-site; EUR 122,000 - 183,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

On-site five days/week

Job summary

Vertex Pharmaceuticals Inc. in Leiden seeks a Senior Manager, Process Engineering to provide technical and strategic leadership across complex manufacturing activities at the Leiden Center.

You will drive early and late-stage development alignment, implement scalable processes, and ensure quality and compliance while partnering with CPI and DSDP stakeholders. As a people leader, you will manage a team, oversee manufacturing strategies, and ensure robust documentation and effective issue

Qualifications

• Must understand GMPs and CMC regulatory considerations in pharma.
• Experience managing pharmaceutical projects.
• Knowledge of technology transfer and validation processes.
• Strong communication and collaboration skills across levels.

Responsibilities

• Serve as technical resource in process engineering areas and align to short-term objectives.
• Develop and implement tools, standards, and practices for continuous improvement.
• Represent Process Engineering on cross-functional CMC teams for late/early-stage development decisions.
• Lead manufacturing strategy for technology transfers and process validations with master plans and protocols.
• Build relationships with suppliers of materials, technologies, and resources.
• Evaluate process performance using statistical methods and lead improvement initiatives.
• Resolve complex manufacturing issues with data-driven and timely investigations.
• Support Leiden Center compliance with quality and regulatory requirements.
• Lead and develop staff with financial accountability.

Skills

GMPs & CMC

Project management

Technology transfer

Validation

Cross-functional collaboration

Data analysis & DOE

Education

Bachelor's degree in a relevant field

Master's degree in a relevant field

PhD in a relevant field

Job description

Job Description General Summary:

The Senior Manager, Process Engineering reports to the Senior Director of Manufacturing. The role is an emerging leadership position within the organization, providing technical, strategic, and operational leadership across complex manufacturing activities. This individual represents the Process Engineering function in cross‑functional settings and helping to advance late and early - stage process and product development while reducing commercialization risk. The Senior Manager builds productive stakeholder relationships, translates departmental priorities into actionable plans, and leads a team of employees in delivering high‑quality, compliant, and scalable outcomes. The position also supports the technical and compliance needs of CPI and DSDP, partnering closely with relevant stakeholders to ensure manufacturing activities are aligned with applicable quality, regulatory, and business requirements. This position reports to the Senior Director of Manufacturing and supports operations at the Leiden Center. The Senior Manager serves as a key Process Engineering partner for CPI and DSDP, ensuring their technical and compliance needs are addressed through effective planning, issue resolution, documentation, and cross‑functional collaboration.

Key Duties and Responsibilities:

• Serve as a technical resource in one or more process engineering areas, adapting departmental plans and priorities to meet short‑term operational objectives.
• Contribute to the development and implementation of departmental tools, standards, and best practices that support consistent execution and continuous improvement.
• Represent Process Engineering on cross‑functional CMC teams, influencing late and early -stage process and product development decisions.
• Develop and execute manufacturing strategies for technology transfers and process validations, including strategic master plans, protocols, and technical reports.
• Establish and maintain effective working relationships with key suppliers of materials, technologies, and manufacturing resources.
• Evaluate process performance through statistical process control methods; identify, prioritize, and lead continuous improvement initiatives across the product lifecycle.
• Resolve complex manufacturing issues by applying new perspectives to existing solutions and support timely, scientifically sound resolution of quality investigations.
• Support CPI and DSDP technical and compliance needs at the Leiden Center, ensuring process engineering activities, documentation, and decisions meet applicable quality and regulatory expectations.
• Lead and develop assigned staff; as a people manager, assume appropriate financial accountability and human resource responsibilities.

Knowledge and Skills:

• Advanced knowledge of GMPs and associated CMC regulatory considerations in a pharmaceutical environment.
• Demonstrated experience managing projects within the pharmaceutical industry.
• Strong understanding and practical application of technology transfer and validation processes.
• Strong communication, collaboration, and team‑building skills, with the ability to connect effectively at all organizational levels.
• Ability to manage multiple high‑priority projects concurrently and influence stakeholders in a strong‑matrix environment.
• Mastery of complex data analysis, mathematical modeling, Working knowledge of Quality by Design (QbD) principles and design of experiments methodology and implementation.

Education and Experience:

• Bachelor's degree in relevant field PhD and 2+ years, or Master's and 5+ years, or Bachelor's and 8+ years.

Pay Range:

$140,000 - $210,000

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law.

Flex Designation:

On‑Site Designated Flex Eligibility Status: In this On‑Site designated role, you will work five days per week on‑site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail] Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion‑dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1‑mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH‑dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.