Materials Management Technical Support, Senior Manager

Vertex Pharmaceuticals Inc (US); Leiden; On-site; EUR 109,000 - 164,000; Full time

Job summary

Vertex Pharmaceuticals Inc (US) is seeking an experienced Senior Manager to develop and execute the Materials Management strategy supporting manufacturing and commercial material control. You will own SOPs, drive digital system integration, and partner across Manufacturing, PD, QC, and Facilities to enable compliant material flows and 24x7 manufacturing.

Responsibilities include leading cross-functional teams, defining KPIs, managing deviations and change controls, and guiding a team of

Qualifications

• BS or MS in Supply Chain or a related discipline or equivalent combination of education and experience.
• 6 years of experience supporting site-based materials management in cell and gene therapy manufacturing, biopharmaceutical manufacturing, or related pharmaceutical environment.
• 3 years of leadership experience.
• Proficient in ERP/MRP/WMS and related supply chain systems.

Responsibilities

• Own the development of SOPs, work instructions, and related documentation for commercial Materials Management and tech transfer of new products and programs.
• Represent Materials Management at cross-functional daily management meetings, maintaining visibility to technical issues and action plans across warehouses and production staging areas.
• Develop strategy and procedures for integrating Materials Management digital systems (ERP, MRP, WMS, Serialization, etc.) with compliant material flows.
• Identify KPI and reconciliation processes.
• Serve as the primary escalation point for Material Management issues; coordinate resolution with SMEs and communicate status to management.
• Support deviation management, CAPA, and change control activities as needed.
• Lead Technical Support initiatives, contribute to strategy development, and lead team resources to achieve Material Operations objectives.
• Oversee sustained performance and continuous improvement of cell and gene therapy Materials Management processes.

Skills

Manufacturing support operations

Warehouse management

ERP/MRP/WMS

Technical problem-solving

Communication & presentation

Lean Six Sigma Green/Black Belt

Education

BS/MS in Supply Chain or related discipline

3 years leadership experience

Tools

Serialization

Job description

Job Description General Summary

Reporting to the Director, Materials Operations, this role is responsible for developing and executing the Materials Management Technical Support strategy for Manufacturing support operations, material control process design, compliant material flows, and system reconciliation in support of product commercialization. The individual will also support key Materials Management systems and processes, including change controls, risk assessments, deviations, and GMP documentation. This role provides oversight of commercial material control process development, materials management system design, warehouse material flows and performance monitoring. The Senior Manager will collaborate cross-functionally with Manufacturing, Process Development (PD), Quality Control (QC), Operational Quality, Facilities, Operations, and other stakeholders to enable compliant material flows and sustained manufacturing support.

Key Duties and Responsibilities

• Own the development of SOPs, work instructions, and related documentation required for commercial Materials Management, and tech transfer of new products and programs
• Represent Materials Management at cross-functional daily management meetings, maintaining visibility to technical issues and action plans across warehouses and production staging areas
• Develop strategy and procedures for integrating Materials Management digital systems (ERP, MRP, WMS, Serialization, etc.) with compliant material flows.
• Identify Key Performance Indicators (KPI) and reconciliation processes
• Serve as the primary escalation point for Material Management issues; coordinate resolution with subject matter experts and communicate status to management
• Support deviation management, CAPA, and change control activities, as needed.
• Serve as the process SME for Materials Management.
• Support Materials Management investigations and root cause analyses
• Partner with Managed Service Provider program managers to monitor performance, optimize schedules, and update statements of work to support evolving business requirements
• Identify warehouse and material control innovations to drive efficiencies at scale
• Implement standard work, process confirmations, and support tiered management initiatives
• Design and maintain physical and system material flows, deploying Kanban systems and other methodologies to support 24x7 manufacturing
• Lead Technical Support initiatives, contribute to strategy development, and lead team resources to achieve Material Operations objectives.
• Oversee the sustained performance and continuous improvement of cell and gene therapy Materials Management processes.
• Ensure compliance with all regulatory, corporate, and Quality System requirements

Knowledge and Skills

• Demonstrated experience in manufacturing support operations, warehouse management, and cGMP material control
• Proficient in ERP/MRP/WMS and related supply chain systems
• Strong technical problem-solving, technical writing, and presentation skills.
• Lean Six Sigma Green Belt or Black Belt preferred
• Strong sense of urgency, with the ability to escalation promptly and communicate transparently with stakeholders and management
• Ability to work independently with minimal supervision, manage multiple priorities, and support several projects simultaneously
• Strong interpersonal, collaboration, and teamwork skills

Education and Experience

• BS or MS in Supply Chain or a related discipline or equivalent combination of education and experience
• 6 years of experience supporting site-based materials management in cell and gene therapy manufacturing, biopharmaceutical manufacturing, or a related pharmaceutical environment
• 3 years of leadership experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range: $125,400 - $188,200

Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.

From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation: On-Site Designated Flex Eligibility Status

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.