Postdoc: RNA Ensemble Dynamics & Small-Molecule Interaction

University of Groningen via AcademicTransfer; Netherlands; On-site; EUR 52,000 - 68,000; Full time

Benefits offered by this job

End-of-year bonus

Holiday allowance

Job summary

University of Groningen is seeking a postdoctoral researcher for the RNA Structural Dynamics Group at the Groningen Biomolecular Sciences and Biotechnology Institute (GBB).

The project focuses on RNA conformational ensembles and how small molecules reshape them to influence RNA function. You will employ SHAPE/DMS mutational profiling, ensemble deconvolution, and functional assays in cells, with opportunities to supervise PhD/MSc students.

Qualifications

• PhD in Molecular Biology, Biochemistry, Chemical Biology, Biophysics, RNA Biology, Bioinformatics or related field, completed or near completion.
• Hands-on RNA biochemistry or RNA structure probing (SHAPE, DMS, mutational profiling) is a strong asset.
• Experience with small-molecule/RNA interactions, compound screening or biophysical binding assays is desirable.
• Familiarity with sequencing data analysis (Unix/shell, Python, R); RNA structure prediction/ensemble analysis a plus.
• Strong scientific output relative to career stage (publications, conference contributions).
• Enthusiasm for interdisciplinary collaboration and strong written/spoken English.

Responsibilities

• Map how small molecules reshape RNA conformational ensembles using chemical probing and ensemble deconvolution.
• Screen and characterize ensemble-repartitioning compounds.
• Define binding sites and thermodynamic/kinetic basis of repartitioning with chemistry/structural biology partners.
• Link RNA structure to function via reporter assays, translation and splicing readouts.
• Develop methods for high-throughput profiling of RNA structural changes.
• Publish and present findings; supervise PhD and MSc students.

Skills

RNA biochemistry

RNA structure probing

ensemble analysis

computational analysis

english communication

scientific output

Education

PhD in Molecular Biology/Biochemistry

Tools

Unix/shell

Python

R

Job description

University of Groningen is seeking a postdoctoral researcher for the RNA Structural Dynamics Group at the Groningen Biomolecular Sciences and Biotechnology Institute (GBB).

The project focuses on RNA conformational ensembles and how small molecules reshape them to influence RNA function. You will employ SHAPE/DMS mutational profiling, ensemble deconvolution, and functional assays in cells, with opportunities to supervise PhD/MSc students.