Postdoc Position in Medicinal Chemistry

Utrecht University - Faculty of Science; Utrecht; Sur place; EUR 41 000 - 64 000; Plein temps

Résumé du poste

Utrecht University - Faculty of Science in Utrecht, Netherlands, invites applications for a postdoctoral position in Medicinal Chemistry. The role focuses on discovering and developing Piezo1 inhibitors for sickle cell disease, combining virtual screening, AI techniques and organic synthesis.

You will work with UMC Utrecht, access modern labs, and contribute to translational efforts while expanding expertise in synthetic and computational medicinal chemistry.

Qualifications

• PhD in Medicinal Chemistry completed.
• Experience in organic synthesis of drug-like compounds.
• Experience in molecular modelling and docking to create bioactive compounds.
• Excellent written and spoken English.

Responsabilités

• Conduct discovery and development of novel Piezo1 inhibitors for sickle cell disease.
• Utilize virtual screening, AI techniques and organic synthesis to optimize inhibitors.
• Collaborate with researchers at UMC Utrecht and support translational activities.

Connaissances

PhD in Medicinal Chemistry

Organic synthesis of drug-like

Molecular modelling/docking

Proficiency in English

Formation

PhD in Medicinal Chemistry

Description du poste

Postdoc Position in Medicinal Chemistry

Utrecht University - Faculty of Science

Utrecht, Netherlands

€ 3.706 - € 5.760 per month gross

Your job

As a postdoc, you will play a key role in the discovery and development of novel Piezo1 inhibitors for sickle cell disease, combining virtual screening, AI-techniques and organic synthesis. Initial inhibitors have already been identified, providing a starting point for further optimization and broader screening. You will work closely with researchers at UMC Utrecht where compounds will be assayed. The project combines fundamental research with translational potential and offers opportunities to interact with experts in the field through periodic user committee meetings.

You will work in the Chemical Biology and Drug Discovery division of the Utrecht Institute of Pharmaceutical Sciences. The division houses around 60 researchers with expertise in preparative chemistry linked to disease research, carbohydrates and glycoscience, RNA in disease, immunology and drug discovery.

You will have access to modern synthetic labs, state of the art analytical equipment, biolabs and large scale computation facilities. Regular in person meetings with our partner group at the UMC will support the close collaboration on this project. Our goal is to advance successful compounds in subsequent translational activities.

As a postdoctoral researcher, you will have the opportunity to develop your expertise across synthetic and computational medicinal chemistry and apply modern approaches to compound discovery and optimization.

Your qualities

• a completed PhD in Medicinal Chemistry;
• experience in organic synthesis of drug-like compounds;
• experience in molecular modelling/docking experience in the creation and development of bioactive compounds;
• proficiency in written and spoken English.

Deadline 18 November