Postdoc Position in Engineering Microbiome-Immune-Pathogen Interaction in Infant Gut

1000scholars; Amsterdam; Sur place; EUR 41 000 - 64 000; Plein temps

Résumé du poste

The University of Amsterdam invites applications for a Postdoctoral position in Engineering Microbiome-Immune-Pathogen Interaction in the infant gut. The project joins gut-on-a-chip tech, organoids and microbiome methods to study early immune development and pathogen interactions.

The successful candidate will establish anaerobic gut-microbiome-on-a-chip platforms, co-culture organoid-derived epithelium with immune cells, and collaborate across a multidisciplinary team at Amsterdam UMC.

Qualifications

• PhD in Biomedical Engineering or closely related field.
• Hands-on experience with bioengineering, biomaterials, organoids or microfluidic systems.
• Experience with anaerobic microbial cultivation and characterization.
• Fluent English with first-author publication evidence.

Responsabilités

• Establish a gut-microbiome-on-a-chip platform for infant gut studies.
• Design and fabricate mesofluidic gut models for experiments.
• Co-culture organoid epithelium with immune cells and SynComs.
• Coordinate collaboration across engineers, microbiologists and translational researchers.
• Present findings at conferences and publish in peer-reviewed journals.

Connaissances

Bioengineering

Organoids

Microfluidic systems

Anaerobic cultivation

Team collaboration

English writing/presentation

Formation

PhD in Biomedical Engineering or related field

Outils

Organoid culture

Gut-on-a-chip platforms

Microfluidic devices

Description du poste

Postdoc Position in Engineering Microbiome-Immune-Pathogen Interaction in Infant Gut

UvA - University of Amsterdam

Amsterdam, Netherlands

€ 3,706 - € 5,760 per month gross

Do you want to investigate how the microbiome acquired in early life influences innate immunity and pathogen infection in vulnerable infants? Join an NWO Vidi project that combines advanced gut-on-a-chip technology, organoid models and microbiome approaches.

What you will do

• establish an anaerobic gut-microbiome-on-a-chip platform tailored to the human infant gut and investigate how early colonisation by commensal bacteria or pathobionts affects the development and function of the infant gut microbiome, innate immune system and mucosal barrier;
• design and fabricate mesofluidic gut models using the available research facilities;
• co-culture organoid-derived intestinal epithelium, immune cells and synthetic microbial communities (SynComs) that reflect infant gut physiology;
• coordinate and maintain the collaboration between mechanical engineers, microbiologists and translational microbiome researchers at Amsterdam UMC;
• present research findings at scientific conferences and publish results in peer-reviewed journals.

What we ask of you

• a degree (PhD, or equivalent) in Biomedical Engineering, Cell Biology, Molecular Biology, Pharmacology, Biochemistry, or closely related fields. Candidates in the final stages of obtaining their degree are eligible to apply;
• an excellent background in bioengineering, biomaterials, hands-on experience of primary cell culture, organoids, or microfluidic systems;
• experience on or willing to learn anaerobic microbial cultivation and characterization techniques;
• a problem-solving mindset and a strong motivation;
• detail-oriented and can perform team-oriented in a multi-disciplinary team as well as independently;
• fluent in English, both writing and speaking, demonstrated by first-author peer-reviewed publication;
• experience in academic writing and presentation.

Deadline 13 October