Postdoc myelin imaging

KNAW (Nederlandse Akademie van Wetenschappen); Amsterdam; On-site; EUR 42,000 - 54,000; Full time

Job summary

The Netherlands Institute for Neuroscience is seeking a highly motivated postdoctoral researcher to study oligodendrocyte myelin sheaths in brain tissue in health and disease. You will leverage advanced microscopy to reveal biophysical and molecular mechanisms of myelin remodeling, in collaboration with Dr.

Rogier Min at the Amsterdam Leukodystrophy Center. The role requires a recent PhD in neuroscience, experience with single-cell electrophysiology or live functional imaging, mouse brain-tissue

Qualifications

• PhD obtained within the past four years in neuroscience or a related research field.
• Demonstrated experience with single-cell electrophysiology and/or live functional imaging from neurons and/or glia (e.g. 2P/SCoRe).
• Experience (>2 yrs) with brain-tissue preparation methods, preferably involving mouse models.
• Demonstrated capacity to publish research findings in peer-reviewed journals.
• Highly proficient in spoken and written English.
• Experience supervising master/PhD students in research projects.
• Proficiency with programming languages (Python, MATLAB, R) is a plus.

Responsibilities

• A PhD obtained within the past four years in neuroscience or a related research field.
• Demonstrated experience with single-cell electrophysiology and/or live functional imaging from neurons and/or glia (e.g. 2P/SCoRe).
• Experience (>2 yrs) with brain-tissue preparation methods preferably involving mouse models.
• Demonstrated capacity to publish research findings in peer-reviewed journals.
• Highly proficient in spoken and written English.
• Experience supervising master/PhD students in research projects.
• Excellent teamwork and communication skills.

Skills

Single-cell electrophysiology

Live functional imaging

Mouse brain-tissue preparation

Publish in peer-reviewed journals

English proficiency

supervise master/PhD students

Programming (Python)

Programming (MATLAB)

Programming (R)

Education

PhD in neuroscience or related field

Tools

2P/SCoRe

Job description

We are seeking a highly motivated postdoctoral researcher with strong technical expertise to study oligodendrocyte myelin sheaths in brain tissue in health and disease.

Many brain disorders, including rare genetic white matter disorders (leukodystrophies) and more common diseases such as Multiple Sclerosis, are characterized by white matter pathology including myelin swelling (vacuolization), damage, loss, or remodeling. Recently, it was found that myelin swelling is not always the start of myelin loss, but can be followed by repair (Arafa et al. Science 391, eadr4661, 2026). Neuronal activity contributes to myelin swelling, but the mechanisms and dynamics underlying myelin swelling and repair are poorly understood.

Leveraging advanced microscopy approaches, you will investigate myelin in living tissue (Higgins, Al-Naqib et al. 10.64898/2026.05.15.725074) to determine the biophysical and molecular mechanisms associated with myelin remodeling. This project is a collaboration with Dr. Rogier Min of the Amsterdam Leukodystrophy Center (ALC), Amsterdam UMC. Well-validated mouse models for various leukodystrophies offer opportunities to study myelin swelling and remodeling in disease contexts, taking an important step towards a better understanding of this understudied but common phenomenon and building bridges to the clinic.

What you will be contributing

• A PhD obtained within the past four years in neuroscience or a related research field.
• Demonstrated experience with single-cell electrophysiology and/or live functional imaging from neurons and/or glia (e.g. 2P/SCoRe).
• Experience (> 2 yrs) with brain-tissue preparation methods preferably involving mouse models.
• Demonstrated capacity to publish research findings in peer-reviewed journals.
• Highly proficient in spoken and written English.
• Experience supervising master/PhD students in research projects.
• Excellent teamwork and communication skills.
• Certification under Article 9 of the Dutch Experiments on Animals Act, or a comparable EU certification for experimental animal use, is an advantage.
• Proficiency with programming languages (Python, MATLAB, R) is a plus.

What do we offer?

You will be joining a highly collaborative neuroscience research environment and benefit from state-of-the-art infrastructure. The Kole group is renowned for fundamental cellular neuron-glia studies of myelinated axons. The team has new high-end in vitro and in vivo electrophysiological infrastructure, optogenetic and high-speed one- and two-photon imaging setups. Through close collaboration with Dr. Min at the Amsterdam Leukodystrophy Center, you will have the opportunity to investigate myelin remodeling in clinically relevant disease models, adding a strong translational dimension to the project.

This is a full-time position, initially for one year. Subject to satisfactory performance, the contract will be extended for an additional two years. You will have ample opportunities to further develop your scientific knowledge and technical skills through courses offered by the Academy, participation in (inter)national conferences, and additional opportunities for personal development.

About the Netherlands Institute for Neuroscience

The Netherlands Institute for Neuroscience is a leading fundamental neuroscience research institute in Amsterdam. It provides a critical mass of scientists spanning more than 27 nationalities and neuroscience facilities in a highly interactive, dynamic, multicultural environment, with English as the working language.

Applying for a Certificate of Good Conduct can be part of the employment procedure.