PhD position in the Artegiani & Hendriks group

Prinses Máxima Centrum; Utrecht; On-site; EUR 36,000 - 49,000; Full time

Job summary

Prinses Máxima Centrum in Utrecht invites applications for a PhD position in the Artegiani & Hendriks group. The project focuses on human brain organoids to understand development and disease, using CRISPR-Cas engineering and organoid technologies.

The successful candidate will have completed a Master’s degree with wet lab experience, including organoid culture and basic molecular techniques. The lab operates in an international setting with English as the working language.

Qualifications

• Master's degree completed with strong wet lab experience.
• Experience with organoid culture is a plus.
• Familiarity with basic molecular techniques is desired.

Responsibilities

• Develop and apply human brain organoid models.
• Perform transcriptomic analyses and genome engineering.
• Collaborate in an international, English-speaking team.

Skills

Organoid culture

Bioinformatics tools

Teamwork

Education

Master's degree

Tools

CRISPR-Cas

Job description

PhD position in the Artegiani & Hendriks group

3.228 - 4.346

We are looking fora highly ambitiousand enthusiasticPhD candidate who is eager to join our lab. This positionfocuses on the use and development of human brainorganoids, with the overarching goal to understandmechanisms of human brain development and disease,and to unravel the link between the two.

Research focus

We welcome candidates with a strong interest in developmental biology, organoidtechnology, and disease modelling. This position is part of the EU-funded Marie Curidooctoral network (VISI-ON-BRAIN) that connects different countries with theoverarching aim to develop cutting-edge human in vitro and in silico biomedical toolsto better understand the biology of brain disease/disorders (see:https://visi-onbrain.eu/ ).You will employ techniques such as organoid cultures (pluripotent stem celland tissue-derived), transcriptomic analyses, CRISPR-Cas engineering, and otherstate of-the-art tools.

We are looking for candidates that have completed their Master education and havestrong theoretical and wet lab experience, including cell culture and basic moleculartechniques. Experience with organoid culture and bioinformatic tools is a pro. We arelooking for a motivated, academic-oriented candidate that has team-working abilitiesand wants to be part of a team of enthusiastic scientists. The group and the instituteareinternationaland the work language is English. Following the MSCA mobility rule, the candidate may not have lived in the Netherlands more than 12 months in the 3yearsimmediatelybefore the recruitment date.

Our job offer

A temporary, full-time PhD position for a total duration of 4 years (36 hours/week), in an ambitious and dynamic team. You will initially be contracted for a period of 1 year, after which your performance will be evaluated, and the contract may be extended for the remaining years. The Princess Máxima Centeroperatesaccording to the collective labor agreement ‘caoalgemeneziekenhuizen’.Your gross monthly salary willbe in FWG 45-6 and willinclude an 8,33% gross monthly salary holiday allowance and8,33 %end-of-year bonus.

The Princess Máxima CenterforPediatricOncology is an integrated hospital and research institute, which integrates healthcare,researchand education onpediatriccancer, ina single locationin Utrecht. Our institute aims to provide the highest level of care for all children with cancer, withoptimalquality of life.Thecenterbrings together the best possible care and scientific research, creating a unique interdisciplinary institute forpediatriconcology in Europe.

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More information?

For more information about the Artegiani & Hendriks lab and research, visit:[www.bendellab.com](http://www.bendellab.com/).You are welcome to contact both Group Leaders via email [e-mail] and [e-mail].