PhD spatial proteomics

AcademicTransfer; Nederland; On-site; EUR 36,000 - 45,000; Full time

Benefits offered by this job

8.3% end-of-year bonus

Public transport reimbursement

Bike scheme

BeFrank pension

Job summary

Amsterdam UMC Research BV in the Netherlands seeks a highly motivated researcher to design and execute proteomics studies on human brain tissue and iPSC-derived neurons to understand cell-type-specific vulnerability in Frontotemporal dementia (FTD).

You will contribute to translational neuroscience through advanced single-cell and spatial omics technologies and participate in scientific reporting and publications.

Qualifications

• Master\'s degree in neuroscience, biomolecular science, or biochemistry.
• Proven expertise and skills with molecular and cellular work as part of an internship.
• Experience with programming and data analysis (Python, R). Expertise with omics datasets is a strong advantage.
• Strong written and verbal communication skills in English.

Responsibilities

• design and execute proteomics studies to identify cell-type specific vulnerability;
• perform experiments in human postmortem FTD brain tissue and patient iPSC-derived neuronal cell cultures;
• aid in data analysis and integration of -omics datasets to characterize cell-specific functional dysregulation and cellular crosstalk;
• contribute to scientific reporting, publications, and regulatory-ready data packages;
• report on your findings in regular work meetings, conferences, and scientific publications in reputable journals.

Skills

Python

R

Omics data analysis

English communication

Education

Master\'s degree in neuroscience, biomolecular science, or biochemistry

Job description

Organisation/Company Amsterdam UMC Research Field Neurosciences » Neurobiology Neurosciences » Neurochemistry Researcher Profile First Stage Researcher (R1) Application Deadline 15 Nov 2026 - 22:59 (UTC) Country Netherlands Type of Contract Temporary Job Status Not Applicable Hours Per Week 36.0 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Frontotemporal dementia (FTD) encompasses a group of neurodegenerative diseases that progressively affect behavior, movement, personality and/or language. We aim to identify the molecular and cellular causes of FTD that trigger its onset and early progression with the aim to design evidence-based treatment.
We are looking for a highly motivated researcher to join our team. You will design and execute proteomics studies on human brain tissue of sporadic patients and human iPSC-derived neurons. The aim is to understand the molecular and cellular dysfunctions that lead to cell-type-specific vulnerability that may be causative to FTD through highly innovative single-cell and spatial (prote)-omics technologies.
Would you like to know more about the different phases within the PhD trajectory? You can read more about this on this page .
As a member of our team, you will:

• design and execute proteomics studies to identify cell-type specific vulnerability;
• perform experiments in human postmortem FTD brain tissue and patient iPSC-derived neuronal cell cultures;
• aid in data analysis and integration of -omics datasets to characterize cell-specific functional dysregulation and cellular crosstalk;
• contribute to scientific reporting, publications, and regulatory-ready data packages;
• report on your findings in regular work meetings, conferences, and scientific publications in reputable journals.

This position offers a unique opportunity to contribute to translational neuroscience in a dynamic team of proteomic and neuroscience researchers in the search for fundamental insights with real-world therapeutic impact. You have:

• a master's degree in neuroscience, biomolecular science, or biochemistry;
• proven expertise and skills with molecular and cellular work as part of an internship;
• experience with programming and data analysis (Python, R). Expertise with omics datasets is a strong advantage;
• strong written and verbal communication skills in English.

We are looking for the following personality traits:

• excellent organisational and management skills;
• working diligently and with high accuracy;
• a team player who enjoys collaborating in an interdisciplinary environment;
• a creative and independent thinker who takes initiative.

Additional Information

• You will be employed by Amsterdam UMC Research BV.
• A contract for 12 months, with the intention to extend for a total of four years. The Guideline PhD contract applies to this vacancy.
• Classification in salary scale OIO: € 3.217 to € 4.077 gross for full-time employment (depending on experience). In addition to a good basic salary, we offer 8.3% end-of-year bonus. Calculate your net salary here .
• Holiday hours: 194.4 per year for full time and a possibility to save additional hours.
• 100% reimbursement for public transport travel costs. If you travel by foot, bicycle, or car, a mileage allowance of €0.21 per km applies (up to a maximum of 40 km one way by car).
• Do you prefer walking or cycling? Take advantage of our good bike scheme.
• Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.

Watch this video with more information about joining Amsterdam UMC Research BV.

Additional comments

During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.
The first round of interviews is scheduled for November 24, 2026. The second round of interviews is scheduled for December 15, 2026.
If you have any questions about this position, please feel free to contact Claudia Ctortecka, SCAPE Unit Lead, via [e-mail] .
A reference check, screening and hiring assessment may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).
Internal candidates will be given priority over external candidates in case of equal suitability.
Acquisition in response to this vacancy will not be considered.