PhD position: Blood vessels and dementia

Amsterdam UMC; Amsterdam; On-site; EUR 36,000 - 45,000; Full time

Benefits offered by this job

12-month contract

8.3% end-of-year bonus

Public transport reimbursement

Bike scheme

BeFrank pension

Job summary

Amsterdam UMC Research BV invites a motivated graduate researcher to join a project on dementia, focusing on cerebral vascular systems and preclinical models of CAA. You will conduct studies in animals and examine whether the blood-brain barrier is affected and how interventions alter progression.

Techniques include MRI, immunostaining, confocal microscopy and ex vivo assays on vessels. The contract is for 12 months with possible extension to four years under Guideline PhD terms.

Qualifications

• Degree in Biomedical Sciences, Neuroscience or Cardiovascular Sciences.
• Interest in preclinical neuroscience or cardiovascular research.
• Experience with MRI or imaging techniques is a plus.
• Article 9 status or eligibility to obtain it.

Responsibilities

• Conduct preclinical studies using animal models for dementia research.
• Investigate blood-brain barrier integrity in a CAA model.
• Apply MRI, immunostaining, confocal microscopy and ex vivo vessel assays.
• Contribute to project progression and data interpretation.

Skills

MRI

Imaging techniques

Preclinical research

Neuroscience interest

Education

Degree in Biomedical Sciences

Degree in Neuroscience

Degree in Cardiovascular Sciences

Tools

Confocal microscopy

Immunostaining

Job description

About your role

In this project, you will conduct preclinical studies using animal models, including a model for human CAA. You will investigate whether the blood-brain barrier is disrupted in this model and whether interventions targeting the blood-brain barrier influence the course of CAA.

You will use a range of techniques to study these processes, including:

• MRI;


• immunostaining;


• confocal microscopy;


• ex vivo assays on blood vessels.

About you

We are looking for a graduate researcher with an interest in dementia, the cerebral vascular system and preclinical research. You have:

• a degree in Biomedical Sciences, Neuroscience or Cardiovascular Sciences;


• an interest in preclinical research into neuroscience or the cardiovascular system;


• experience with MRI or other imaging techniques, which is an advantage;


• experience with preclinical research in neuroscience or the cardiovascular system, which is an advantage;


• Article 9 status, or at least eligibility to obtain Article 9 status.

Our offer

• You will be employed by Amsterdam UMC Research BV.


• A contract for 12 months, with the intention to extend for a total of four years. The Guideline PhD contract applies to this vacancy.


• Classification in salary scale OIO: € 3.217 to € 4.077 gross for full-time employment (depending on experience). In addition to a good basic salary, we offer 8.3% end-of-year bonus. Calculate your net salary here.


• Holiday hours: 194.4 per year for full time and a possibility to save additional hours.


• 100% reimbursement for public transport travel costs. If you travel by foot, bicycle, or car, a mileage allowance of €0.21 per km applies (up to a maximum of 40 km one way by car).


• Do you prefer walking or cycling? Take advantage of our good bike scheme.


• Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.

Watch this video with more information about joining Amsterdam UMC Research BV.