PhD: CFD-Driven LNP Purification for Cancer Nanomedicine

Delft

On-site

EUR 31,000 - 41,000

Full time

4 days ago

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Job summary

TU Delft is offering a PhD position in Scalable Lipid Nanoparticle Purification Technologies within SPARC, a cross-disciplinary program spanning Chemical Engineering and Process & Energy. You will engineer purification systems for lipid-based drug delivery streams, using CFD modelling, membrane materials, and modular filtration designs, with industrial partners.

The four-year appointment includes competitive salary and professional doctoral training through the TU Delft Graduate School, with

Qualifications

MSc or equivalent in Chemical Engineering, Process Engineering, Mechanical Engineering, Nanotechnology or related field.
Analytical mindset with ability to work across computational and experimental domains.
Excellent English communication and ability to work in a multidisciplinary team.
Experience in CFD simulations or pharmaceutical downstream processes is a plus.

Responsibilities

Compute CFD simulations to study flow, diffusion and filtration in tangential flow filtration systems.
Develop correlations to model fouling build-up and its impact on filtration capacity.
Design novel flow geometries to maximize throughput and minimize mechanical stress on LNPs.
Explore modularisation options for quick replacement of filtration system components.
Experimentally verify alternative membranes for LNP purification.
Experimentally verify modularisation options for the purification train, including quick connectors.