Postdoc in Cross-disciplinary Research in our 'Bio-microfluidics' Team

Delft University of Technology; Delft; On-site; EUR 41,000 - 64,000; Full time

Job summary

Delft University of Technology is seeking a motivated Post-doc researcher for a Cross-disciplinary Research position in the Bio-microfluidics Team. The project develops a predictive lymphatic on-a-chip platform to study subcutaneous bioavailability and aims to reduce animal testing while accelerating therapeutic development.

We seek candidates with a PhD in a relevant field and expertise in microfluidics, imaging, and cell culture, who are creative, analytical, and collaborative.

Qualifications

• Ph.D. in a relevant field such as chemical engineering, physics, electrical engineering, biophysics, bioengineering, materials science or similar.
• Prior experience with microfluidics, fluorescence imaging, confocal imaging, micro‑scal flow or mammalian cell culture is highly desirable.
• Creative, open-minded and proactive.
• Excellent experimental and analytical skills.
• Good team player.
• Good English communication and writing skills.

Responsibilities

• Contribute to developing a predictive lymphatic on-a-chip platform for drug absorption studies.
• Collaborate across disciplines to integrate a vascularized barrier for physiological relevance.
• Validate the platform with diverse biomolecules and optimize formulation and microenvironmental factors.
• Work with the TU Delft team and external pharma collaborations within the TKI-PPS project.

Skills

Microfluidics

Fluorescence imaging

Confocal imaging

Micro-scale flow

Mammalian cell culture

Creative and proactive

Experimental skills

Analytical skills

Team player

English communication

Education

PhD in chemical engineering / physics / EE / biophysics / bioengineering / materials science

Tools

Confocal imaging

Mammalian cell culture

Microfluidics hardware

Job description

We are seeking a highly motivated Post-doc researcher for the position of Postdoc in Cross-disciplinary Research in our 'Bio-microfluidics' Team, with an interest in cross-disciplinary research to join our "bio-microfluidics team" at TU Delft.

Job description

• Are you inspired by the potential to use microfluidics for cancer research?
• Are you passionate to develop ogran-on-a-chip for drug screening applications?
• Would you thrive in a high-end, interdisciplinary research environment dedicated to drug bioavilailibty?

This project develops a predictive lymphatic on a chip platform to study and improve the subcutaneous bioavailability of theraputics. The advanced 3D microfluidic system mimics human lymphatic transport and, for the first time, integrates a vascularized barrier to enhance physiological relevance. It enables mechanistic analysis of therapeutic absorption, distribution, and blood–lymphatic interactions, including applications for small molecules, viral vectors and CAR T therapies. The model will be validated using diverse biomolecules and optimized for evaluation of formulation, dosage, and microenvironmental factors. Ultimately, the platform aims to accelerate therapeutic development while reducing reliance on animal testing and improving translational predictability.

The project is part of our TKI-PPS research project via close collaboration with phrama, which aims to develop a novel bioavailability-on-a-chip platform that addresses a critical unmet need in biologics development.

Job requirements

We are looking for candidates that meet the following criteria:

• Ph.D. degree in a relevant field such as chemical engineering, physics, electrical engineering, biophysics, bioengineering, materials science or similar;
• Prior experience with microfluidics, fluorescence imaging, confocal imaging, micro‑scal flow or mammalian cell culture is highly desirable;
• Creative, open-minded and proactive;
• Excellent experimental and analytical skills;
• Good team player;
• Good English communication and writing skills.

TU Delft (Delft University of Technology)

Working at TU Delft means contributing to solutions that really make a difference.

At TU Delft, our people make the difference. With their knowledge and curiosity, our staff provide a high-quality education and conduct pioneering research that extends beyond the campus. You will have the opportunity to take the initiative, work with others, and grow as a professional. Working at TU Delft means join an international community of professionals and students. Together, we create knowledge, innovations, and solutions that help move the world forward.

Faculty Applied Sciences

Faculty/Department: Faculty of Applied Sciences

With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. Our scientists conduct ground‑breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics.

Conditions of employment

• Duration of contract is 2 years. Temporary.
• A job of 38-40 hours per week.
• FTE: 1,0
• Salary range: €3706 - €5760
• Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.
• An excellent pension scheme via the ABP.
• The possibility to compile an individual employment package every year.
• Discount with health insurers on supplemental packages.
• Flexible working week.
• Every year, 232 leave hours (at 38 hours). You can also sell or buy additional leave hours via the individual choice budget.
• Plenty of opportunities for education, training and courses.
• Partially paid parental leave
• Attention for working healthy and energetically with the vitality program.

Will you need to relocate to the Netherlands for this job? TU Delft is committed to make your move as smooth as possible! The HR unit, Coming to Delft Service, offers information on their website to help you prepare your relocation. In addition, Coming to Delft Service organises events to help you settle in the Netherlands, and expand your (social) network in Delft. A Dual Career Programme is available, to support your accompanying partner with their job search in the Netherlands.

As part of knowledge security, TU Delft conducts a risk assessment during the recruitment of personnel. We do this, among other things, to prevent the unwanted transfer of sensitive knowledge and technology. The assessment is based on information provided by the candidates themselves, such as their motivation letter and CV, and takes place at the final stages of the selection process. When the outcome of the assessment is negative, the candidate will be informed. The processing of personal data in the context of the risk assessment is carried out on the legal basis of the GDPR: performing a public task in the public interest.