Intern, Clinical Pharmacology & Quantitative Science

StudentJob; Utrecht; Hybrid; EUR 7,100 - 9,600; Full time

Benefits offered by this job

Pension

Health insurance and wellness benefits

Paid time off

Employee support programs

Job summary

Genmab is offering a Masters internship in Quantitative Translational Pharmacology in Utrecht, Netherlands. You will contribute to a project modeling tumor growth inhibition to improve animal study decisions and patient exposure predictions.

You will integrate data from in vitro, preclinical, and clinical studies, calibrate models, and collaborate with a multidisciplinary team. Hybrid work and a 6–12 month duration are expected.

Qualifications

• Enrollment in a Master’s programme in Biopharmaceutical Sciences, Biomedical Sciences, Drug Innovation, Pharmacy, or similar in the Netherlands.
• Must be a mandatory part of degree for graduation; graduates or extraneous internships not considered.
• Basic knowledge of cancer biology/immunology.
• Familiarity with PK/PD, PBPK, and/or QSP modeling including calibration/evaluation.
• Experience with programming, preferably in R.

Responsibilities

• Implement a tumor growth inhibition model within the translational PBPK/PD framework.
• Compile, curate, and analyze in vitro, preclinical, and clinical datasets for translational modeling.
• Compare in vitro-only vs. combined in vitro/in vivo strategies for predicting patient exposure.
• Investigate reducing/refining preclinical animal studies via modeling.
• Perform exploratory analyses and evaluate model performance with diagnostics.
• Present findings through reports and presentations to the team.

Skills

R programming

PK/PD modeling

Quantitative modeling

English communication

Education

Master's student in Biopharmaceutical Sciences or related

Tools

R

Nonlinear mixed-effects modeling

Job description

At Genmab, we are dedicated to building extra[not]ordinary® futures, together, by developing antibody products and groundbreaking, knock-your-socks-off KYSO antibody medicines® that change lives and the future of cancer treatment and serious diseases. We strive to create, champion and maintain a global workplace where individuals' unique contributions are valued and drive innovative solutions to meet the needs of our patients, care partners, families and employees.

Our people are compassionate, candid, and purposeful, and our business is innovative and rooted in science. We believe that being proudly authentic and determined to be our best is essential to fulfilling our purpose. Yes, our work is incredibly serious and impactful, but we have big ambitions, bring a ton of care to pursuing them, and have a lot of fun while doing so.

Does this inspire you and feel like a fit?

The Role

Can quantitative modeling help reduce the need for animal studies in drug development? While in vitro assays provide valuable mechanistic insights, they do not always fully predict how a therapy will perform in vivo. Animal studies can bridge that gap, but they are time-consuming, resource-intensive, and should only be used where they truly add scientific value.

Within Genmab's Quantitative Translational Pharmacology team, you will contribute to an exciting project that explores how quantitative modeling can help optimize this process. By combining historical preclinical and clinical data, you will investigate whether in vivo tumor growth inhibition studies improve the prediction of efficacious patient exposure compared with an in vitro-only approach. Ultimately, the goal is to support smarter drug development decisions while contributing to the 3Rs principles (Replacement, Reduction and Refinement) by identifying opportunities to reduce or refine the use of animal studies.

During this internship, you will integrate a tumor growth inhibition module into Genmab's translational PBPK/PD modeling framework and work with a diverse range of datasets, including molecular and cellular assays, pharmacokinetic data, tumor growth inhibition studies, and clinical exposure-response data. Your work will contribute to the development of a reusable modeling workflow that can support future discovery projects.

You will become part of an experienced multidisciplinary team where you'll receive guidance while also having the opportunity to work independently. The exact direction of the project can be tailored to your interests and academic background, allowing you to deepen your expertise in quantitative pharmacology within a dynamic biotechnology environment.

Responsibilities

• Implement a tumor growth inhibition model within Genmab's translational PBPK/PD modeling framework.
• Compile, curate, and analyze in vitro, preclinical, and clinical datasets to support translational modeling.
• Compare in vitro-only and combined in vitro/in vivo strategies for predicting efficacious patient exposure.
• Investigate opportunities to reduce or refine preclinical animal studies through quantitative modeling.
• Perform exploratory data analyses and evaluate model performance using appropriate diagnostics.
• Present your findings through clear reports and presentations to colleagues within the team.

Requirements

We're looking for a curious and motivated Master's student who enjoys combining biology, mathematics, and programming to solve complex scientific questions. You also bring:

• Enrollment in a Master's programme in Biopharmaceutical Sciences, Biomedical Sciences, Drug Innovation, Pharmacy, or another relevant discipline at a university in the Netherlands.
• This internship must be a mandatory component of your degree programme required for graduation. Unfortunately, we cannot consider applications from graduates or students seeking an extracurricular internship.
• Basic knowledge of cancer biology and/or immunology.
• Familiarity with PK/PD, PBPK, and/or QSP modeling, including model calibration and evaluation.
• Experience with programming, preferably in R.
• An interest in quantitative modeling and translational pharmacology.
• Strong analytical thinking and a proactive approach to problem solving.
• Excellent communication skills in English and the ability to collaborate in multidisciplinary teams.
• Experience with nonlinear mixed-effects modeling or previous industry experience is considered an advantage but is not required.

General Internship Information

• Duration: 6-12 months
• Start date: 1 November
• Location: Utrecht, the Netherlands
• Working pattern: Hybrid (3 days in the office, 2 days working from home)

The proposed gross annual/monthly base salary range for this position, in the primary location, based on a full time schedule is:

EUR750,00---750,00

The final salary offer will depend on several factors, including your skills, qualifications, and experience.

In addition to base salary, this position is eligible for additional forms of compensation, such as discretionary bonuses and long-term incentives.

When you join Genmab, you become a part of a culture that supports your physical, financial, social, and emotional well-being. Our benefits include, but are not limited to:

• Pension
• Health insurance and wellness benefits
• Paid time off
• Employee support programs

Further details on eligibility for compensation and benefits based on the role will be provided during the recruitment process.

About Genmab

Genmab is an international biotechnology company with a core purpose to improve the lives of patients through innovative and differentiated antibody therapeutics. For 25 years, its hard-working, innovative and collaborative team has invented next-generation antibody technology platforms and harnessed translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab's vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO®) antibody medicines.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X .

Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on your website Job Applicant Privacy Notice (genmab.com) .

Please note that if you are applying for a position in the Netherlands, Genmab's policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the contract.

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