Principal Data Scientist – DDSAI GD

8080-Johnson & Johnson Private Limited Legal Entity; Hyderabad; On-site; INR 1,800,000 - 2,800,000; Full time

Job summary

Johnson & Johnson in Hyderabad is seeking a Principal Data Scientist to lead end-to-end delivery of integrated analytical solutions for clinical-development and trial-operations problems. You will own model development, validation, deployment, and adoption across multiple stakeholders using ML, GenAI, and RWD analytics.

You will collaborate with clinical, operational, and data teams, applying diverse data sources such as EHR, claims, registries, and trial data to generate evidence on patient

Qualifications

• Master’s degree in CS or a quantitative field; PhD preferred.
• At least 5 years of industry experience delivering data-science solutions.
• Proficiency in Python and SQL; experience with ML, NLP, GenAI, and RWD analytics.
• Experience with structured and unstructured clinical/operational data.
• Strong communication and leadership skills.

Responsibilities

• Lead end-to-end delivery of integrated data-science solutions for defined business problems.
• Own solution definition, validation, deployment, and adoption across stakeholders.
• Lead predictive modeling, simulations, optimization, GenAI applications for study planning.
• Apply RWD analytics to generate evidence on patient populations, treatment pathways, feasibility, and risks.
• Mentor junior colleagues and strengthen delivery practices across project teams.

Skills

Python

SQL

ML

GenAI

NLP

RWD analytics

Leadership

Education

Master’s degree in Computer Science or quantitative field

PhD preferred

Tools

LLM development libraries

MLOps tools

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function: Data Analytics & Computational Sciences Job Sub Function: Data Science Job Category: Scientific/Technology All Job Posting Locations: Hyderabad, Andhra Pradesh, India

Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

Job Summary J&J Innovative Medicine – Data, Data Science, and AI - Global Development (DDSAI GD) is seeking a Principal Data Scientist to lead end-to-end delivery of integrated analytical solutions for defined clinical-development and trial-operations business problems. This role owns solution definition, delivery, adoption, and use-case outcomes across connected stakeholder groups using ML, GenAI, optimization, and RWD.

Key Responsibilities Own the end-to-end definition, development, validation, deployment, and adoption of integrated data-science solutions for defined business problems. Lead predictive modeling, simulations, optimization, and GenAI applications for study feasibility, enrollment forecasting, country and site selection, protocol design, and operational planning. Apply clinical, operational, cost, and RWD—including EHR, claims, registries, and clinical-trial data—to generate evidence on patient populations, treatment pathways, feasibility, and operational risks. Lead RWD analytics that inform protocol feasibility, eligibility criteria, recruitment and retention, study design, comparative evidence, and external-control use cases. Develop LLM-enabled workflows for information extraction, protocol comparison, data harmonization, clinical-concept interpretation, and targeted workflow automation. Partner with clinical, operational, technology, and data stakeholders to frame questions, manage trade-offs, and translate outputs into adopted recommendations and measurable use-case outcomes. Apply model-validation, MLOps, documentation, privacy, data-quality, and responsible-AI standards; contribute reusable code, data assets, and technical patterns. Communicate methods, model outputs, assumptions, limitations, and decisions clearly to technical and nontechnical audiences. Mentor junior colleagues and strengthen delivery practices across project teams.

Required Qualifications Master’s degree in computer science, engineering, biostatistics, health economics, biomedical informatics, applied mathematics, or another quantitative discipline; PhD preferred. At least 5 years of industry experience leading end-to-end delivery of data-science solutions using ML, predictive modeling, optimization, NLP, GenAI, or RWD analytics. Demonstrated experience defining, validating, deploying, and driving adoption of analytical solutions that inform clinical-development, clinical-operations, or real-world evidence decisions. Hands-on experience with structured and unstructured clinical, operational, or RWD data, including multimodal modeling and time-series or simulation methods. Proficiency in Python and SQL, modern ML, optimization, and LLM-development libraries, and reproducible MLOps practices. Strong communication, stakeholder-management, and technical-leadership skills.

Preferred Qualifications Experience in healthcare, pharmaceutical development, MedTech, clinical development, or clinical operations. Experience applying RWD methods to clinical-trial design, including target-trial emulation, propensity methods, survival analysis, or time-to-event analysis. Experience delivering analytical products or applications used by clinical or business teams.

Required Skills: Preferred Skills: Advanced Analytics, Coaching, Critical Thinking, Data Analysis, Data Privacy Standards, Data Quality, Data Reporting, Data Savvy, Data Science, Data Visualization, Digital Fluency, Econometric Models, Organizing, Process Improvements, Strategic Thinking, Technical Credibility, Workflow Analysis

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at https://www.jnj.com/.

Our Credo calls on us to respect the dignity of every individual and create an environment for all people to thrive. Throughout the recruitment process - from application through hiring - we are committed to providing reasonable accommodations/adjustments for qualified candidates with disabilities. If you need support at any stage of the recruitment process, please complete our candidate accommodation request form so we can assist you.