Director, Systems Modelling & QSP

Syngene International Limited; Bengaluru; On-site; INR 3,500,000 - 7,000,000; Full time

Job summary

Syngene International Limited in Bengaluru, India, seeks a Director - Systems Modelling & QSP to lead modelling across small molecules, biologics, and advanced modalities. You will build mechanistic, systems-level and quantitative approaches to inform translational decisions and clinical development.

Lead an integrated team spanning QSP, systems biology, PK/PD, PBPK and AI-enabled modelling; drive model-informed drug discovery and development while expanding scientific capabilities for client

Qualifications

• 15 years of relevant experience in pharma or CRO/CDMO settings.
• Leadership of QSP or mechanistic modelling teams.
• Demonstrated track record influencing drug discovery and development decisions.
• Experience managing global stakeholders and client-facing engagements.
• Strong understanding of pharmaceutical R&D and scientific workflows.

Responsibilities

• Develop long-term roadmaps for QSP, systems biology, PBPK and translational modelling.
• Lead responsible for model-informed drug discovery and development.
• Identify emerging technologies in digital biology and AI-driven modelling.
• Mentor scientists and foster a culture of scientific excellence.
• Ensure compliance with data governance, safety and regulatory standards.

Skills

QSP modelling

Systems biology

PK/PD

PBPK

AI-enabled modelling

Modelling leadership

Education

Ph.D. in QSP or related field

Job description

Date: 31 Aug 2026

Location

Bangalore, KA, IN, 560100

Division

Discovery Services

Job Description

Job Title: Director - Systems Modelling & QSP

Job Location: Bengaluru, India

Department: Computational and Data Sciences

About Syngene: Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.

Safety

At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit

Mandatory expectation for all roles as per Syngene safety guidelines

• Overall adherence to safe practices and procedures of oneself and the teams aligned
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Compliance to Syngene’ s quality standards at all times
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time

Core Purpose Of The Role

The Director, Systems Modelling & Quantitative Systems Pharmacology (QSP) will lead Syngene's modelling and simulation capabilities across small molecules, biologics and advanced therapeutic modalities. The role will be responsible for developing and applying mechanistic, systems-level and quantitative modelling approaches that improve understanding of disease biology, therapeutic mechanisms, translational outcomes and clinical development decisions.

This leader will be responsible for an integrated modelling team spanning QSP, mechanistic systems biology, PK/PD, PBPK and AI-enabled modelling approaches to support both internal programmes and global client engagements. The position will play a critical role in advancing model-informed drug discovery and development while creating differentiated scientific capabilities for Syngene.

Role Accountabilities

• Develop long-term capability roadmaps spanning QSP, systems biology, mechanistic modelling, PBPK and translational modelling.
• Partner with Head, CDS to establish Syngene as a leading partner for model-informed drug discovery and development.
• Identify emerging technologies and opportunities in digital biology, virtual patients, AI-driven modelling and model-informed decision making.
• Lead development and application of systems biology frameworks for translational models, including mechanistic disease, (PB)PK/PD, exposure-response, trial simulation.
• Support target identification, target validation, mechanism-of-action and translational studies through systems-level modelling.
• Drive integration of AI, machine learning and mechanistic modelling approaches.
• Mentor scientists and foster a culture of innovation, collaboration and scientific excellence.
• Uphold Syngene's values of Safety, Quality, Integrity and Compliance.
• Ensure adherence to data governance, security, privacy and regulatory requirements.
• Promote a strong culture of responsible AI and ethical use of data.
• Support EHSS initiatives and organisational compliance programmes.

Syngene Values

All employees will consistently demonstrate alignment with our core values

• Excellence
• Integrity
• Professionalism

Experience

• 15 years of relevant experience in either pharma or CRO/CDMO organizations.
• Demonstrated leadership of leadership in QSP or mechanistic modelling.
• Track record of supporting drug discovery and development decisions through quantitative modelling.
• Experience managing global stakeholders and client-facing engagements.
• Strong understanding of pharmaceutical R&D and scientific workflows

Education: Ph.D. in a related field (QSP, systems biology, applied mathematics, pharmaceutical sciences)

Other Competencies Required For The Role

• Excellent people skills and ability to instill a culture of collaboration.
• Working in multidisciplinary environments.
• Strong customer and service delivery mindset.
• Confident and well-practiced language and interpersonal skills.
• Impeccable ethics and integrity along with an exposure to a multi-cultural work environment.

Equal Opportunity Employer

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.