Overview
The R&D Business Capability Manager Associate serves as the interface between Business and Digital/Data on foundational data capabilities or needs across R&D. This role is responsible for identification of key use cases across R&D, high-level data solutioning (e.g., data strategy, governance/standards, management, infrastructure needs), and oversight of day-to-day operations for their specific data capability.
Responsibilities
- Work in collaboration with R&D Data Office leadership, business, and R&D Digital subject matter experts.
- Partner with key stakeholders across R&D functions to identify data-related needs and initiatives (e.g., data catalog, master and reference data management, data products) and design innovative data solutions to support business priorities.
- Partner with R&D Digital stakeholders to oversee data-related activities and verify data functionality from ingest through access.
- Drive program management of initiatives and capabilities; ensure on-schedule/on-time delivery and proactive management of risks/issues.
- Establish ways of working across all partner functions for specifically assigned capabilities/initiatives.
- Annotate genomic variants (e.g., SNVs, indels, CNVs, SVs) using open source or proprietary tools on relevant databases to assess functional and clinical relevance.
- Integrate genomic annotations with pathway databases, transcriptomic data, and disease ontologies to generate hypotheses about target biology and mechanism of action.
- Work with multi-omics data sets (e.g., WES, WGS, RNA-seq, scRNA-seq) and curate data pipelines to ensure quality, consistency, and reproducibility of annotations.
- Partner with wet-lab scientists, data scientists, and therapeutic area teams to deliver actionable insights for target validation, biomarker discovery, and patient stratification.
- Contribute to the development and maintenance of automated workflows, reproducible pipelines and databases.
- Document methodologies and present results in internal meetings, reports, and collaborative discussions with cross-functional stakeholders.
Deliverables
- Develops business case development, requirement identification, and use case development for business functions.
- Implements business process definition, process performance, process execution, process management, and continuous improvement opportunities.
- Maintain genomic databases, pipelines, tools and platforms.
About you
- Experience: M.S. + 5 years or Ph.D. + 3 years hands-on experience in bioinformatics, preferably in a pharma, biotech, or translational research setting.
- Proficient in scripting languages (e.g., Python, R, Bash) and bioinformatics tools for genomic annotation.
- Solid understanding of human genetics, disease biology, and functional genomics data sets.
- Familiarity with ontologies and biological knowledgebases (e.g., GO, KEGG, Reactome, DisGeNET).
- Experience working with NGS data and variant interpretation in the context of drug discovery or precision medicine.
- Experience with workflow languages (e.g., Nextflow, Snakemake, WDL); knowledge of clinical genomics standards (e.g., HGVS nomenclature, ACMG classification).
- Familiarity with target identification and validation pipelines or biomarker discovery programs.
- Familiarity with Pharma R&D processes and technology; ability to build business relationships and understand end-to-end data use and needs.
- Diplomatic and stakeholder management skills across business, technology, and partners.
- Demonstrated strong attention to detail, quality, time management and customer focus.
- Excellent written and oral communication skills; strong networking, influencing and negotiating skills; and superior problem-solving skills.
- Demonstrated willingness to make decisions and take responsibility; excellent interpersonal skills (team player).
- People management skills either in matrix or direct line function; M.S. or Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related discipline.