BRL (Research Associate) - R&D - Analytical - 2

USV; Navi Mumbai; On-site; INR 600,000 - 900,000; Full time

Job summary

BRL's Analytical Development Lab seeks an experienced Scientist to lead analytical deliverables for Biologics projects across markets. You will perform method development, qualification, technology transfer, biosimilarity assessment, forced degradation, and characterization using MS, HPLC/UPLC, CE, and related techniques.

The role requires 2–5 years in an analytical development setting with hands-on HPLC/UPLC experience and proficiency in RP/HIC/IEX/SEC chromatography and capillary

Qualifications

• 2–5 years experience in an analytical development laboratory.
• Hands-on experience in HPLC/UPLC is mandatory.
• Experience with multiple chromatography modes (RP, HIC, IEX, SEC) and capillary electrophoresis (CIEF, CZE, CE-SDS) required.

Responsibilities

• Plan and execute experiments independently with emphasis onMS, HPLC/UPLC, CE-based analyses.
• Apply analytical techniques including chromatography, electrophoresis, spectrophotometry, and colorimetric assays for Biotherapeutics.
• Maintain data integrity and adhere to procedures; prepare and review technical reports.
• Ensure timely delivery of analytical activities and coordinate with team members.

Skills

HPLC

UPLC

RP chromatography

HIC chromatography

IEX chromatography

SEC chromatography

Capillary electrophoresis

CIEF

CZE

CE-SDS

Higher order structure analysis

Mass Spectrometry

Education

BSc./MSc. Biotechnology

B.Tech/MTech Biotechnology

Job description

Role Objective: Will work in the Analytical Development Lab of BRL, taking responsibility for the analytical deliverables of Biologics Projects for all markets. Deliverables involve, but are not limited to, Method Development, Qualification, Technology transfer, Biosimilarity assessment, Forced degradation, and Characterization activities.

KEY RESPONSIBILITIES

• Responsible for the independent planning and execution of experiments, with a major focus on Mass Spectrometry, HPLC, UPLC, and CE-based analysis.
• Apply analytical techniques including, but not limited to, Chromatography, Electrophoresis, Spectrophotometry, and Colorimetric assays for Biotherapeutics.
• Perform assigned analytical activities by following established systems and procedures.
• Maintain target dates for all assigned analytical activities.
• Maintain strict data integrity during all analysis processes.
• Prepare and review technical reports and contribute directly to troubleshooting efforts required for laboratory instrumentation.
• Communicate effectively with other team members and teams regarding the generated analytical data.

STAKEHOLDER INTERACTION

Type of Interaction: Internal

• Interaction with: Other team members and teams.
• Nature of Interaction: Communicate effectively regarding the analytical data.

Type of Interaction: External

• Interaction with: Not explicitly specified in the vacancy details.
• Nature of Interaction: Not explicitly specified in the vacancy details.

JOB REQUIREMENTS

Professional Experience and Relevant Skills

• Experience: 2-5 years of experience within an analytical development laboratory setting.
• Skills: Hands-on experience in HPLC and UPLC is mandatory. Knowledge and hands-on experience of different chromatography modes like RP, HIC, IEX, SEC, etc., is required. Knowledge and hands-on experience of different capillary electrophoresis techniques (CIEF, CZE, CE-SDS, etc.) is required. Hands-on experience with Higher order structure analysis (DSC, CD, Fluorescence, FTIR, etc.) is an advantage.
• Technical Expertise: Experience working on biotherapeutic proteins like monoclonal antibodies, Fc fusion, peptibody, or any candidate biosimilars is required. Method Development and Qualification experience is a must. An understanding of analytical deliverables involving CQA, QTPP, Analytical similarity, Forced degradation studies, and Specifications setting is preferred.

Academic Qualifications & Certifications:

• Educational Qualification: BSc./MSc. Biotechnology or B.Tech/Mtech. Biotechnology