Software Engineer, Web Application

Iambic Therapeutics, Inc; Dublin; On-site; EUR 90,000 - 120,000; Full time

Job summary

Iambic Therapeutics, Inc. is seeking an engineer to own and evolve a secure, cloud-based web app that scientists use to interact with our ML-driven drug-discovery platform.

You will build features end-to-end across the UI, API layer, and service layer, ensuring the web surface remains a thin, secure adapter over shared services. You’ll work with chemists and biologists, design usable interfaces for a technical audience, and help with onboarding materials and in-product guidance.

Qualifications

• Strong full-stack Python experience with production apps.
• Experience rendering server UI using HTMX.
• Experience with FastAPI or similar backend services.
• Experience with relational databases.
• Ability to design usable interfaces for scientists.
• Familiarity with web security basics (authn/authz).
• Comfort with containerization and CI/CD.
• Strong written communication and distributed teamwork.

Responsibilities

• Build and evolve a Python web app, API, and workflows.
• Work across stack: HTMX UIs, FastAPI route handlers, service layer.
• Collaborate with chemists and biologists to gather requirements.
• Design user-friendly interfaces for non-engineers; contribute docs.
• Keep web layer as a thin contract over services; avoid business logic.
• Enforce authorization and surface safe error states.
• Participate in design reviews, code reviews, and documentation.

Skills

Full-stack Python

HTMX UI

FastAPI

Relational databases

Web security basics

Containerization

CI/CD

Written communication

Tools

uvicorn

pixi

PostgreSQL

S3

AWS ECS

Job description

JOB SUMMARY

Iambic is building a secure, cloud-based platform for running our ML-driven drug-discovery workflows.

You'll own and evolve our web application - the primary surface through which scientists interact with our drug-discovery platform. You'll work across the full stack, from the interface through the FastAPI HTTP layer down to the service layer, building features that are usable by non-engineers (chemists, biologists) and trustworthy with sensitive scientific data.

This role suits an engineer who enjoys shipping end-to-end features on a product surface, cares about UX for a technical-but-non-developer audience, and is comfortable that the web layer is a thin, secure adapter over a shared service layer rather than a place for business logic. This position is based out of our new Ireland office.

KEY RESPONSIBILITIES

• Build and evolve a Python web application - its interface, the API layer behind it, and the supporting workflows.

• Work across the stack: server-rendered UIs (HTMX), FastAPI route handlers, and the underlying service layer.

• Work with domain experts (primarily chemists and biologists working on drug discovery projects) to understand requirements.

• Design interfaces that are usable and legible for non-engineers; contribute to onboarding materials and in-product guidance.

• Keep the web/HTTP layer a thin contract over the service layer - no business logic in route handlers - so the same logic is reusable by future entry points.

• Treat sensitive data with care: enforce authorization and access scoping on every request, and surface clear, safe error states rather than silent failures.

• Participate in design discussions, code reviews, and documentation.

QUALIFICATIONS

• Strong full-stack engineering skills with production Python, including building server-rendered UIs (e.g. HTMX).

• Experience building and operating production web applications or SaaS-style products.

• Comfort with HTTP API design and well-structured backend services (FastAPI or similar).

• Experience with relational databases.

• A track record of building usable interfaces for real users and iterating on feedback.

• Comfortable working closely with scientific or domain users on data-intensive problems.

• Awareness of web security fundamentals (authn/authz, session handling, handling sensitive data) preferred

• Familiarity with containerization and CI/CD preferred.

• Strong written communication and the ability to work effectively in a distributed team.

TECH STACK & ENVIROMENT

• Python with modern tooling (e.g. uv, pixi)

• FastAPI with a clean service-layer architecture

• Server-rendered UIs (HTMX)

• PostgreSQL and object storage (S3)

• AWS (ECS and related services)

• Infrastructure-as-code and automated CI/CD; containerized services

• Agentic coding tools (e.g. Claude Code) as part of day-to-day development

ABOUT IAMBIC THERAPEUTICS

Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

MISSION & CORE VALUES

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.