PostDoc Lvl 1 or 2, UCD Biomolecular and Biomedical Science, 18 months

EURAXESS Ireland; Dublin; Hybrid; EUR 42,000 - 54,000; Full time

Job summary

University College Dublin's Chromatin Mechanisms in Disease laboratory seeks a postdoctoral fellow to investigate how dysregulation of H2AK119ub1 relates to disease. The project uses functional genomics, biochemistry and proteomics, including CUT&Tag, Captify, RNA-seq and mass spectrometry.

The successful candidate may work computationally, wet-lab or in combination, with strong support for professional development and opportunities to pursue external funding during the appointment.

Qualifications

• PhD or near-completion with strong research track in chromatin biology.
• Experience in functional genomics and proteomics techniques.
• Ability to work in computational biology, wet-lab or hybrid settings.

Responsibilities

• Investigate how dysregulated H2AK119ub1 contributes to disease.
• Apply CUT&Tag, Captify, RNA-seq and mass spectrometry to study PRC1/PR-DUB pathways.
• Engage in data analysis and experimental design with opportunities for funding pursuits.

Skills

Computational biology

Wet-lab

Hybrid capability

Tools

CUT&Tag

Captify

RNA-seq

Immunoprecipitation

Mass spectrometry

Job description

Organisation/Company University College Dublin Research Field Environmental science Researcher Profile Recognised Researcher (R2) Application Deadline 19 Oct 2026 - 23:00 (UTC) Country Ireland Type of Contract To be defined Job Status Full-time Hours Per Week To be defined Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The Chromatin Mechanisms in Disease laboratory ( https://conwaychromatinlab.com/ ) at University College Dublin, led by Dr. Eric Conway, are recruiting a postdoctoral fellow to work on understanding the mechanisms through which the repressive histone modification H2AK119ub1 is dysregulated in disease. This position will be funded through a Wellcome Trust award.

Histone H2A lysine 119 mono-ubiquitination (H2AK119ub1) is a repressive histone modification that is catalysed by the PRC1 complex and erased by the PR-DUB complex. Variants in critical subunits of each complex are known to be the causative event in diverse human diseases, such as AML and chromatinopathies. This project will investigate how pathogenic variants in members of the PRC1 and PR-DUB complexes contribute to changes in H2AK119ub1 using cancer and neurodevelopmental disease model systems.This will encompass a range of functional genomics, biochemistry and proteomics methods to investigate the precise impact that variants have on PR-DUB and PRC1 function – using methods such as CUT&Tag, Captify, RNA-seq, immunoprecipitation followed by mass spectrometry and high throughput pooled CRISPR screens.

The role of the applicant will be either computational biology, wet-lab or a hybrid of both depending on the successful candidates expertise. There will be strong opportunities for continued professional development as part of UCD Research Careers Framework and through attendance at external training courses and conferences. The applicant will be strongly encouraged and supported to pursue external funding opportunities during the period of the appointment in line with the development of their own career prospects and to further the overall research activities of the group.

Appointment on the above range will be dependent upon qualifications and experience.

Closing date: 12:00 noon (local Irish time) on 19 October 2026.

UCD do not require assistance from Recruitment Agencies. Any CVs submitted by Recruitment Agencies will be returned.

The PD1 position is intended for early-stage researchers, either just after completion of a PhD or for someone entering a new area for the first time. If you have already completed your PD1 stage in UCD or will soon complete a PD1, or you are an external applicant whose total Postdoctoral experience, inclusive of the duration of the advertised post, would exceed 4 years, you should not apply and should refer to PD2 posts instead.

The PD2 post is intended for researchers who have completed PD1. As with the PD1, if you have already completed your PD2 stage in UCD or will soon complete a PD2, or your total Postdoctoral experience, inclusive of the duration of the advertised post, would exceed 6 years, you should not apply and refer to Research Fellow posts instead.