VP, Therapeutics Design & In Silico Discovery

Evotec WD; Abingdon; On-site; GBP 152,000 - 203,000; Full time

Job summary

Evotec seeks a VP, Head of Therapeutics Design to lead its in silico therapeutics design capability. This role unites computational chemistry, generative modelling, and predictive ADMET with biology targets across small molecules, peptides, and degraders.

The holder will shape strategy, grow the team, and industrialise capabilities at scale. The position reports to the EVP and partners with Strategy, Portfolio and Commercial to enable collaborations and monetise capabilities.

Qualifications

• PhD in computational or medicinal chemistry or related field.
• Experience in biotech/pharma environments with drug discovery design.
• Proven track record progressing molecules through discovery and contributing to assets.

Responsibilities

• Set and own the technical vision for therapeutics design across modalities.
• Own ADMET/Safety as a strategic pillar with data-grounded decisions.
• Ensure design informed by patient-derived data and biology targets.
• Deliver contributions to joint flagship programmes with Strategy & Portfolio and Commercial.
• Industrialise repeatable, validated design methods across partner programmes.
• Build and lead a multi-site scientific team with career development paths.
• Support partnerships and licensing with evidencing in-silico value.

Skills

Computational chemistry

Medicinal chemistry

Structure-based design

Ligand-based design

Molecular dynamics

FEP methods

Generative design

Predictive ADMET

Protein modelling

ML in drug discovery

Education

PhD in computational/medicinal chemistry

Biotech/pharma drug discovery experience

Senior leadership experience

Tools

RDKit

Python (scientific)

Cloud computing

High-performance compute

Job description

Evotec seeks a VP, Head of Therapeutics Design to lead its in silico therapeutics design capability. This role unites computational chemistry, generative modelling, and predictive ADMET with biology targets across small molecules, peptides, and degraders.

The holder will shape strategy, grow the team, and industrialise capabilities at scale. The position reports to the EVP and partners with Strategy, Portfolio and Commercial to enable collaborations and monetise capabilities.