Vice President, Oncology Regulatory Strategy

ASTRAZENECA UK LIMITED; Cambridge; Hybrid; GBP 180,000 - 240,000; Full time

Job summary

AstraZeneca, a leading biopharma based in the United Kingdom, seeks a VP, Regulatory Head to set the regulatory vision for its oncology medicines and to partner with senior leaders to define strategy across small molecules and biologics.

You will lead Executive Directors and Global Regulatory Leaders, drive governance, and advance digital data use in regulatory work to accelerate decisions, submissions, and approvals.

Qualifications

• PhD in a scientific discipline or equivalent.

Responsibilities

• Set the long-term oncology regulatory strategy and align priorities.
• Lead Executive Directors and Global Regulatory Leaders.
• Partner with SVP and senior leaders to shape portfolio development.
• Oversee regulatory strategies for small molecules and biologics.
• Advance digital, data, and automation in regulatory science.
• Represent AstraZeneca at key forums and health authorities.
• Review submissions and ensure compliance and scientific rigor.
• Manage area budgets and contribute to the regulatory financial plan.

Skills

Regulatory leadership

Portfolio strategy

Global collaboration

Budget management

Executive communication

Education

PhD in a scientific discipline

Job description

Are you ready to set the regulatory vision that accelerates life-changing oncology medicines to patients? As VP, Regulatory Head, you will steer a significant share of our oncology portfolio, partnering with the SVP and senior leaders across science and the business to define strategy at critical milestones and guide portfolio pillars and development programs. You will lead Executive Directors and Global Regulatory Leaders in delivering integrated, high-impact strategies across small molecules and biologics. Your leadership will translate breakthrough science into globally aligned pathways to approval and access, advance the use of digital and data in regulatory work, and ensure the regulatory voice shapes decisive portfolio choices. How would you harness regulatory intelligence and external influence to create faster, smarter routes from development to approval and launch?,

• Functional leadership and vision: Serve on the leadership team to set the long-term oncology regulatory strategy, translating ambition into clear priorities and measurable outcomes.
• Regional Centre of Excellence: Lead and evolve the Centre to strengthen consistency, capability building, and operational excellence.
• Executive partnership: Deputise for the SVP when required, ensuring continuity of strategy, decisions, and stakeholder engagement.
• Portfolio strategy and execution: Define and align global regulatory strategies for assigned programs, balancing near-term milestones with longer-term investments.
• Digital and data strategy: Advance digital approaches, data use, and automation in regulatory science to accelerate decisions and submissions.
• People leadership and succession: Lead Executive Directors and Global Regulatory Leaders; grow talent, plan succession, and foster a high-performance, learning-focused culture.
• Enterprise decision influence: Embed the regulatory perspective in business and portfolio decisions, shaping trade-offs and risk-benefit choices at governance forums.
• Business development alignment: Partner on in- and out-licensing and external collaborations, ensuring regulatory diligence and strategic fit.
• Regulatory intelligence and policy: Anticipate changes in the regulatory environment and translate insights into proactive program strategies.
• External representation: Represent the company at key forums, including DIA and trade associations, while expanding trusted relationships with global health authorities.
• Submission excellence: Review and approve submission documents, ensuring scientific rigor, clarity, and compliance.
• Best practice and compliance: Champion best practices across therapy areas and uphold policies, procedures, and quality standards.
• Financial stewardship: Manage area budgets and contribute to the function's financial plan, directing resources to the highest-value opportunities.
  PhD in a scientific discipline or equivalent.
• Substantial global experience at the VP or Executive level, or equivalent, delivering positive outcomes across portfolios of varying scientific and clinical complexity, including product approval and launch, with oncology experience and knowledge.
• Broad experience in drug development.
• Strong people and project management experience.
• Successful contribution to a wide range of regulatory approvals at regional or global level.
• Demonstrated track record in portfolio and people leadership from a Regulatory Sciences perspective.
• Established and recognized influential relationships with global health authorities in the relevant disease or therapeutic area.
• Experience serving on key governance committees relevant to the area.
• Experience leading global functional teams, managing change, and building Regulatory Sciences and disease-area capabilities.
• Ability to manage a budget of $10M or more and contribute to the financial plan for ORSS.

Desirable Skills & Experience

• Proven leadership across small molecules and biologics, including combinations and precision medicine approaches.
• Experience shaping regulatory policy through external consortia, trade associations, or guideline working groups.
• Expertise in innovative clinical development approaches, such as master protocols and adaptive designs, and evidence strategies including real-world data.
• Track record of building Centres of Excellence or transformative capability programs across global, matrixed organizations.
• Companion diagnostics experience and fluency in precision oncology regulatory pathways.
• Demonstrated use of digital tools and automation in regulatory operations and intelligence.
• Deep understanding of global regulatory requirements across the FDA, EMA, and key agencies in Asia-Pacific and Latin America.
• Strong public speaking and influencing skills with senior internal stakeholders and external authorities.
  When we bring unexpected teams together, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace, and challenge perceptions. That is why we work, on average, a minimum of three days per week from the office-while balancing this expectation with individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca

At AstraZeneca, you will help transform cutting-edge oncology science into meaningful value for patients by bringing unexpected teams together to spark bold ideas and decisive action. With a rich pipeline and a culture that empowers ownership, you will shape strategy at scale, influence global standards, and grow your impact while helping deliver therapies that change lives. Lead the strategy that accelerates oncology breakthroughs.Step into this role to shape global approvals, grow future leaders, and leave a lasting mark on patient outcomes.