Senior Staff Scientist

Genome Research Limited (GRL); Hinxton; Hybrid; GBP 53,000 - 64,000; Full time

Job summary

A top-tier scientific research institute in England is seeking an experienced Senior Staff Scientist to support the Haniffa Faculty Group in generating high-quality iPSC and haematopoietic stem cell cultures. The ideal candidate will hold a PhD in a relevant field and possess strong skills in molecular and cellular biology. This role offers a salary range of £53,717-£63,815 and supports a hybrid working model for better work-life balance.

Qualifications

• Diverse research experiences in experimental molecular/cellular biology.
• Robust experience in maintaining hESC and/or hiPSC.
• Strong organizational and communication skills.

Responsibilities

• Support the generation of high-quality iPSC and haematopoietic stem cell cultures.
• Supervise lab members and engage with stakeholders.
• Contribute to research output and support the Group Leader.

Skills

Experimental molecular/cellular biology

In Vitro models (3D organoids, iPSC-derived cells)

Flow cytometry

Immunocytochemistry

Single-cell transcriptomics

Education

PhD in relevant wet-lab subject

Tools

Human cell processing

SOP adherence

Job description

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.

The Haniffa team is seeking an experienced Senior Staff Scientist to support the Haniffa Faculty Group in their generation of high quality iPSC and haematopoietic stem cell cultures for a permanent contract.

About the Team:

Muzlifah Haniffa is a dermatologist pioneering the applications of single cell genomics technologies to understand tissue homeostasis, immunity and disease pathogenesis. A major research goal of the Haniffa laboratory is to decode the development and functional maturation of the human immune system.

The Haniffa Group’s research within the Cellular Genomics Programme applies disruptive cutting-edge techniques to study the genomics of immune cell populations at single-cell resolution and uses advanced computing capabilities to analyse data to reconstruct the immune system within its tissue context during development and adult life.

What you will be doing?

You will have the opportunity to guide, maintain, and continuously improve the wet laboratory haematopeoisis research of the Haniffa Lab. Your role includes:

1. Supporting the generation of high-quality iPSC and haematopoietic stem cell cultures (definitive and primitive haematopoiesis), single-cell datasets, and other wet lab protocols.
2. Helping to supervise lab members.
3. Working closely to engage internal and external stakeholders in the team’s research.
4. Contributing to research output and supporting the Group Leader as required.

About you:

You will have diverse research experiences and technical skills in experimental molecular/cellular biology, including In Vitro models such as 3D organoids and iPSC-derived hematopoietic cells.

PhD in a relevant wet-lab subject (e.g., Cell Biology, Developmental Biology, Immunology) or an equivalent qualification in Biological Sciences.

Robust experience in maintaining hESC and/or hiPSC.

Experience in handling, processing, and storing human cells and tissues.

Attention to detail and adherence to SOPs when performing routine tasks.

Experience in flow cytometry, immunocytochemistry, routine imaging.

Ability to test, implement, and troubleshoot new approaches and techniques.

Experience in single-cell transcriptomics and cDNA library production.

Strong organizational, communication skills, and thorough record-keeping.

Motivated and ambitious to contribute to the team and research goals.

A team player who enjoys collaborative work and building relationships with stakeholders.

Other Information:

Salary per annum (dependent on skills and experience): £53,717-£63,815

Application Process:

Please submit your CV and a Cover Letter (up to two pages each) explaining how you meet the above criteria.

Closing Date: 14th August 2025

We support Hybrid Working, offering flexibility to enhance work-life balance and facilitate collaboration.

Equality, Diversity and Inclusion:

We are committed to an inclusive culture, valuing diversity, and providing support through various staff networks. We aim to create an environment where everyone can thrive.

We also prioritize wellbeing and have initiatives to support health and reduce work-related stress.

Sanger Institute is a signatory of the International Technician Commitment, promoting recognition and career development for technicians.

About Us

At the Sanger Institute, we tackle challenging genomic research questions. Our team delivers impactful science with the aim to solve major global issues, attracting diverse talent to maximize our impact.