Senior Screening Scientist

Novo Nordisk; Oxford; Sur place; GBP 70 000 - 95 000; Plein temps

Résumé du poste

Novo Nordisk in Oxford seeks a Senior Screening Scientist to lead functional genomics strategies for target discovery, validation and maturation. You will collaborate across multidisciplinary teams, blending cutting-edge screening technologies with biological insight to address complex research questions and drive portfolio decisions.

The role requires leadership in automation-ready workflows, data interpretation of large datasets, and mentorship of colleagues, contributing to high‑impact

Qualifications

• PhD in Functional Genomics, Molecular Biology, Cell Biology, Genetics or related field with significant experience.
• Typically 5+ years applying functional genomics in pharma/biotech/academic settings.
• Deep expertise in CRISPR-based functional genomics and screening technologies.
• Proven experience designing and interpreting functional genomics in physiologically relevant cells.
• Experience leading medium-to-high-throughput screening campaigns and translating results into biology insights.
• Experience developing automation-compatible assay workflows and scalable screening.
• Strong knowledge of experimental design, statistics and data analysis of large datasets.
• Track record of scientific innovation through publications, platforms or project contributions.
• Experience leading initiatives and mentoring scientists in multidisciplinary teams.
• Experience with laboratory automation and advanced screening technologies.

Responsabilités

• Lead design and application of functional genomics strategies to identify, validate and mature targets.
• Provide scientific leadership in automation-ready assay workflows with Automation Scientists.
• Design and lead medium-throughput screening campaigns with robust experimental design.
• Drive adoption of functional genomics and automation to scale data generation.
• Integrate diverse datasets to generate actionable insights for project decisions.
• Act as scientific lead within multidisciplinary teams influencing strategy.
• Mentor junior scientists and foster collaborative capabilities.
• Communicate findings to senior stakeholders via presentations and reviews.
• Champion data integrity and FAIR data principles.

Connaissances

Functional genomics

CRISPR-based screening

Automation & screening platforms

Data analysis & statistics

Mentoring & team leadership

Scientific communication

Stakeholder management

Formation

PhD in Functional Genomics / related

Outils

Automation platforms

High-content phenotypic screening

Description du poste

Your impact starts here

As Senior Screening Scientist, you’ll play a leading role in the identification, validation and maturation of novel therapeutic targets across Novo Nordisk's research portfolio. This is an exciting opportunity for an experienced scientist to combine deep expertise in functional genomics, CRISPR technologies, advanced automated screening platforms and human biology to generate transformative insights that drive the next generation of therapies.

What you’ll bring

You are an accomplished scientist with a proven track record of applying functional genomics technologies to solve complex biological problems at scale. You combine scientific depth with strategic thinking, strong collaboration skills and a passion for translating cutting‑edge science into therapeutic opportunities.

To succeed in this role, you will have:

• A PhD in Functional Genomics, Molecular Biology, Cell Biology, Genetics or a related scientific discipline, with significant industrial and/or postdoctoral experience.
• Typically, 5+ years of experience applying functional genomics approaches in pharmaceutical, biotechnology or academic research environments.
• Deep expertise in CRISPR‑based functional genomics, including gene editing, gene perturbation and screening technologies.
• Proven experience designing, executing and interpreting functional genomics studies using physiologically relevant cellular systems.
• Experience leading medium‑to‑high‑throughput screening campaigns and translating results into project‑driving biological insights.
• Experience developing assay strategies that are compatible with laboratory automation and scalable screening workflows.
• Strong knowledge of experimental design, statistics and data analysis, including the interpretation of large and complex biological datasets.
• A track record of scientific innovation demonstrated through impactful publications, platform development, patents or significant project contributions.
• Experience leading scientific initiatives, influencing research direction and contributing to multidisciplinary project teams.
• Experience with laboratory automation, advanced screening technologies and high‑content phenotypic approaches.
• Ability to mentor and develop scientists while fostering a collaborative and high‑performing team environment.
• Excellent communication and stakeholder management skills, with the ability to present complex scientific concepts to diverse audiences.

What you’ll do

As Senior Screening Scientist, you will lead the design and application of functional genomics strategies to support target identification, validation and maturation. Working across multidisciplinary teams, you will combine innovative experimental approaches, advanced screening technologies and biological insight to address complex research questions and inform key portfolio decisions. In this role, you will provide scientific leadership, influence research strategy, champion new technologies and mentor colleagues while delivering high‑impact science in a collaborative research environment.

Your responsibilities will include:

• Leading the design and implementation of functional genomics strategies using siRNA, CRISPR‑based perturbation technologies, gene editing and advanced human cellular models to identify and validate novel therapeutic targets.
• Providing scientific leadership in the development of automation‑compatible assay workflows by partnering with Automation Scientists to ensure assays are robust, scalable and ready for deployment on automated screening platforms.
• Designing and leading medium‑throughput screening campaigns, ensuring robust experimental design, data quality and scientific reproducibility.
• Driving the adoption of emerging functional genomics, screening and automation technologies to scale data generation and strengthen target discovery capabilities.
• Interpreting complex biological datasets and integrating functional genomics, phenotypic and disease biology data to generate actionable insights and inform project decisions.
• Acting as a scientific lead within multidisciplinary project teams, influencing research strategy and contributing to key go/no‑go decisions.
• Building strong cross‑functional collaborations and mentoring junior scientists to advance scientific objectives and develop team capabilities.
• Communicating scientific findings and recommendations to senior stakeholders through presentations, project reviews, publications and external scientific forums.
• Championing scientific excellence, data integrity and FAIR data principles.

In addition, you will contribute to departmental strategy, technology roadmaps and capability‑building initiatives that strengthen TIM's functional genomics and target discovery capabilities.

Who you’ll work with

The Target Identification and Maturation (TIM) department, based at Novo Nordisk Research & Development UK (NNRCO) in Oxford, is part of Novo Nordisk Global Research. TIM plays a pivotal role in discovering, validating, and advancing novel therapeutic targets that address unmet patient needs across Novo Nordisk’s research portfolio. Leveraging cutting‑edge human biology, advanced experimental platforms, computational approaches, and translational science, the department generates insights that enable target identification, mechanistic understanding, and target maturation towards project initiation.

Our multidisciplinary teams work across the target discovery value chain, integrating in vitro and in silico capabilities, functional genomics, screening technologies, data science, and disease biology to uncover and de‑risk new therapeutic opportunities. While maintaining a strong focus on cardiometabolic diseases, including obesity, type 2 diabetes, chronic kidney disease, cardiovascular disease, and related co‑morbidities, TIM also supports the exploration of emerging therapeutic areas and novel biological pathways.

The Oxford research centre thrives on collaboration. We maintain strong partnerships with leading academic institutions, particularly the University of Oxford, as well as biotechnology and technology partners worldwide. As part of a global research organisation, TIM works closely with colleagues in Denmark, Boston, and across Novo Nordisk Global Research to translate scientific discoveries into the next generation of innovative medicines for patients.

What you can expect here

You will join a scientific community where curiosity and patient focus are central to how we work, and where your expertise can help shape important decisions. You will be trusted to take ownership and make your voice heard, while being supported to grow through mentorship, collaboration, and challenging work across therapeutic areas and development stages.

Application Support

We are an equal opportunities employer, and we are committed to an inclusive recruitment process and equality of opportunity for all our applicants. If you are a person with a disability, or if you are neurodivergent and require adjustments during the application or selection process, please email [e-mail]. Please include your name, the role you are interested in, and the type of adjustment you need, so we can support you throughout the process.

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.