Senior Scientist Upstream Process Research Mammalian Cell Culture and Single-Use Bioreactors - Client-dedicated

Thermo Fisher Scientific Inc.; Letchworth; Presencial; GBP 65.000 - 90.000; Jornada completa

Descripción de la vacante

Thermo Fisher Scientific Inc. is seeking a Senior Scientist for the Upstream Process Research team in Stevenage.

The role focuses on operating single-use bioreactors to culture mammalian cells (CHO preferred), executing seed train expansion, feeding strategies, sampling and harvest, while maintaining aseptic conditions. You will generate and interpret process data, ensuring robust manufacturing processes and timely delivery of material for research and downstream applications, in a

Formación

• Degree in Life Sciences, Biotechnology, Biochemical Engineering, Cell Biology, or a related discipline with relevant laboratory experience.
• Hands-on experience culturing mammalian cells, ideally CHO cell lines, in shake flasks and single-use bioreactors.
• Experience operating single-use bioreactor systems and equipment such as controllers, tubing assemblies, pumps, probes, sensors, and sampling systems.
• Strong understanding of upstream process parameters and their impacts.

Responsabilidades

• Operate and monitor single-use bioreactor systems for mammalian cell culture processes, focusing on CHO cell lines.
• Plan, execute, and troubleshoot upstream cell culture experiments including seed train expansion, bioreactor setup, inoculation, feeding, sampling and harvest.
• Apply aseptic technique and good cell culture practice to maintain contamination-free operations.
• Generate, analyze and interpret process data including growth, viability, metabolites, titre, and trends.

Conocimientos

Mammalian cell culture

Bioreactor operation

Upstream process delivery

Data analysis

Experimental design

Team collaboration

Communication skills

Educación

Degree in Life Sciences or related discipline

Herramientas

Single-use bioreactor systems

Controllers & pumps

Analytical instruments

Descripción del empleo

We are seeking a highly motivated Senior Scientist with strong hands-on experience in mammalian cell culture, bioreactor operation, and upstream process delivery to join the Upstream Process Research (UPR) team at client's Biologics Process Research (BPR) in Stevenage.

BPR plays a central role in the early phase biologics portfolio delivering high-quality clonal cell lines and reliable processes to enable technology transfer and the production of clinical material.

This is a primarily lab-based role focused on operating single-use bioreactor systems to culture mammalian cells, supporting robust delivery of material for research and downstream applications and the creation of robust manufacturing processes. The successful candidate will be an organised, proactive experimental scientist with excellent communication skills and the ability to work effectively both independently and within multidisciplinary teams., Operate and monitor single-use bioreactor systems for mammalian cell culture processes, with a primary focus on CHO cell lines.

Plan, execute, and troubleshoot upstream cell culture experiments, including seed train expansion, bioreactor setup, inoculation, feeding strategies, sampling, and harvest.

Apply strong aseptic technique and good cell culture practice to maintain robust, contamination-free operations.

Generate, analyze, and interpret process and cell culture data, including growth, viability, metabolite, titre, and process performance trends.

Maintain accurate, detailed experimental records in laboratory notebooks and data systems.

Work effectively both independently and as part of multidisciplinary matrix teams, collaborating with downstream processing, analytics, automation, and project biology colleagues.

Degree in Life Sciences, Biotechnology, Biochemical Engineering, Cell Biology, or a related discipline, with relevant laboratory experience in the pharmaceutical or biotechnology sector.

Hands-on experience culturing mammalian cells, ideally CHO cell lines, in shake flask and single-use bioreactor formats.

Demonstrated experience operating single-use bioreactor systems and associated equipment such as controllers, tubing assemblies, pumps, probes, sensors, and sampling systems.

Strong understanding of upstream process parameters and their impacts, including pH, dissolved oxygen, temperature, agitation, feeding, osmolality, metabolites etc.

Familiarity with aseptic technique, bioreactor preparation, medium and feed handling, sterile connections etc.

Strong analytical and data interpretation skills, with the ability to identify trends, troubleshoot process performance, and communicate findings clearly.

Excellent organizational skills with the ability to manage workload, coordinate experiments, and meet agreed timelines.

Proven flexibility, collaborative mindset, and strong teamwork abilities.

Strong written and verbal communication skills combined with record keeping and attention to detail.

Desirable Skills

• Experience with high-throughput or automated mammalian cell culture workflows. Experience with ambr automation systems.
• Experience with process development, scale-down models, or optimization of fed-batch or intensified mammalian cell culture processes.
• Familiarity with analytical methods used to assess upstream process performance, such as cell counts, metabolite analysis, titre measurement, or product quality assays.
• Experience working with data analysis, electronic laboratory notebooks, or digital systems used to capture bioprocess data.
• Awareness of good documentation practice and regulated biopharmaceutical working practices

At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on - now and in the future.

Within our Analytical Services team, we have a functional service provider solution, which is an outstanding partnership that allows our customers to use the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits., When you join Thermo Fisher Scientific, you become part of a global team that values passion, innovation, and a commitment to scientific excellence. You'll work in an environment where collaboration and development are part of the everyday experience - and where your contributions truly make a difference.

What we offer:

As well as being rewarded a competitive salary, we have an extensive benefits package based around the health and well-being of our employees. We have a flexible working culture, where PPD clinical research services truly value a work-life balance. We've grown sustainably year on year but continue to offer a collaborative environment, with teams of colleagues eager to share expertise and have fun together. We are a global organization but with a local feel.

Our Mission is to enable our customers to make the world healthier, cleaner and safer. As one team of 100,000+ colleagues, we share a common set of values - Integrity, Intensity, Innovation and Involvement - working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. #StartYourStory with PPD, part of Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued.