Senior Scientist - UPLC Triple Quadrupole

ZipRecruiter; London; On-site; GBP 40,000 - 60,000; Full time

Job summary

A leading biotech company in London is looking for a Senior Bioanalytical Scientist to conduct high-sensitivity bioanalytical work in a regulated lab. The role focuses on operating UPLC-MS/MS instrumentation and developing analytical methods crucial for drug development. Ideal candidates will demonstrate expertise in UPLC and mass spectrometry techniques, thriving in a collaborative and precise scientific environment.

Qualifications

• Demonstrable experience with UPLC and triple quadrupole mass spectrometry using ESI.
• Hands-on use of Waters systems (e.g., Xevo TQ, MassLynx) is desirable.
• Familiarity with GLP/GCLP and regulated workflows is essential.

Responsibilities

• Operate, maintain, and troubleshoot UPLC-MS/MS instrumentation.
• Develop and validate robust bioanalytical methods.
• Ensure compliance with regulatory documentation standards.

Skills

UPLC

triple quadrupole mass spectrometry

method development

Education

Degree in a scientific field

Postgraduate qualification (MSc/PhD)

Tools

Waters systems

Job description

Job Description

Senior Bioanalytical Scientist - Triple quadruple MS - biotech in London

We are seeking a Senior Bioanalytical Scientist with proven expertise in UPLC coupled with triple quadrupole mass spectrometry (ESI), to join a small biotech in London. This is a hands-on, lab-based position in a fully regulated environment supporting high-integrity, high-sensitivity bioanalytical work.

Industry: biotech

Location: On-site in London

Employment Type: Full-time, Permanent

Key Responsibilities:

• Operate, maintain, and troubleshoot UPLC-MS/MS instrumentation (ideally Waters)
• Develop and validate robust, sensitive bioanalytical methods for complex biological matrices
• Perform quantitative analysis in accordance with GLP/GCLP and sponsor-specific protocols
• Ensure data quality, reproducibility, and full compliance with regulatory documentation standards
• Contribute to the delivery of client projects within a collaborative, scientifically rigorous environment

Essential Requirements:

• Demonstrable experience with UPLC and triple quadrupole mass spectrometry using electrospray ionization (ESI)
• Hands-on use of Waters systems (e.g., Xevo TQ, MassLynx) is highly desirable
• Familiarity with GLP and/or GCLP requirements and regulated laboratory workflows
• Strong understanding of method development, sample preparation, and assay validation
• Must have the right to work in the UK

Qualifications:

• Degree in a scientific field
• Postgraduate qualification (MSc/PhD) is but not required if supported by substantial practical experience

This is an excellent opportunity to join a specialist clinical laboratory contributing to essential drug development and translational science. Candidates who value scientific precision, regulatory compliance, and team collaboration will thrive in this role.