Senior Scientist – Solid-State Chemistry & Materials

ASTRAZENECA UK LIMITED; Macclesfield; On-site; GBP 60,000 - 90,000; Full time

Job summary

AstraZeneca UK Limited in Macclesfield seeks a Senior Scientist in Solid-State Chemistry & Molecular Materials Science to strengthen our solid-state science capability, applying molecular-level insight to design innovative pharmaceutical materials.

You will lead development across crystalline and disordered systems, collaborating with formulators, process engineers and external partners to ensure robust products.

Qualifications

• PhD or MSc with equivalent industrial experience in pharmaceutical sciences, chemistry, materials science, spectroscopy or related discipline.
• Deep expertise in molecular-level characterisation of complex pharmaceutical materials, especially amorphous or disordered systems.
• Hands-on solid-state characterisation integrating datasets for mechanistic understanding.

Responsibilities

• Lead solid-state science activities underpinning drug product projects with focus on amorphous/disordered systems.
• Define Critical Molecularly Driven Material Attributes across drug substances and excipients.
• Design and conduct lab-based experiments to assess solid-state risks and drug-excipient interactions.
• Translate mechanistic understanding into practical material, process and product-control strategies.
• Drive digital-first strategies and in silico approaches alongside experiments to accelerate decisions.

Skills

Solid-state chemistry

Molecular materials

Data analytics

In silico modelling

Education

PhD in pharmaceutical sciences

Tools

Python

Chemometrics

Job description

AstraZeneca UK Limited in Macclesfield seeks a Senior Scientist in Solid-State Chemistry & Molecular Materials Science to strengthen our solid-state science capability, applying molecular-level insight to design innovative pharmaceutical materials.

You will lead development across crystalline and disordered systems, collaborating with formulators, process engineers and external partners to ensure robust products.