Senior Scientist – Mechanistic Pharmacology

TN United Kingdom; Babraham; On-site; GBP 40,000 - 70,000; Full time

Job summary

An established industry player in cancer research is seeking a Senior Scientist to lead innovative drug discovery projects. This role offers the chance to design and analyze biochemical assays, collaborate with academic and industry leaders, and contribute to the development of high-throughput screening strategies. With a focus on advancing cancer treatments, you will work in a multidisciplinary team that values ambition and collaboration. This position not only fosters professional growth but also encourages participation in conferences and publications, making it an exciting opportunity for passionate scientists eager to make a meaningful impact.

Benefits

Career Development Opportunities

Participation in Conferences

High-Quality Tools

Wellbeing Support

Qualifications

• Experience in assay development for drug discovery.
• Deep understanding of biochemical assays and detection technologies.

Responsibilities

• Design and develop biochemical assays for cancer targets.
• Collaborate with academic and industry partners on drug discovery.

Skills

Assay Development

Biochemical Assays

High Throughput Screening

Enzyme Mechanisms

Data Analysis

Liquid Handling

Education

BS in Biological Sciences

MSc in Biological Sciences

PhD in Biological Sciences

Tools

Automated Robotics Systems

Statistical Analysis Software

Job description

Social network you want to login/join with:

Senior Scientist – Mechanistic Pharmacology, Babraham

Client:

Cancer Research UK

Location:

Babraham, United Kingdom

Job Category:

Other

-

EU work permit required:

Yes

Job Reference:

2bf2a1337011

Job Views:

8

Posted:

28.04.2025

Expiry Date:

12.06.2025

Job Description:

At Cancer Research UK, we exist to beat cancer

Cancer Research UK’s Drug Discovery team is looking for an experienced and passionate Senior Scientist to lead in designing, prosecuting, and analyzing biochemical assays, including bespoke mechanistic data and High Throughput Screening activities.

This role offers an opportunity for an experienced Senior Scientist to lead drug discovery projects, collaborate with academic PIs and partners, and contribute to the development of HTS strategies using automated robotics systems. The team is multidisciplinary, providing ample opportunities for learning, cross-training, and development. We also encourage participation in conferences, poster presentations, talks, and publications.

About CRUK Drug Discovery

As the world’s largest medical research charity, we have helped bring eleven new cancer drugs to market. We aim to accelerate the development of effective treatments through innovative approaches and collaboration, seeking radical ideas and embracing risk to achieve success.

What will I be doing?

This laboratory-based role focuses on designing and developing physiologically relevant biochemical assays in 384 and 1536 well formats to characterize cancer targets, enable high-throughput screening, analyze structure-activity relationships, and understand mechanisms of action to inform clinical decisions.

The successful candidate will stay abreast of cutting-edge biochemistry, enzymology, and HTS science, working closely with industry and academic partners to advance cancer targets towards patient benefit.

What skills will I need?

We seek an accomplished scientist with:

• A BS, MSc, or PhD in biological sciences such as biochemistry or pharmacology; relevant experience may substitute education.
• Significant experience in assay development within drug discovery, including enzyme and small molecule inhibitor mechanisms.
• Deep understanding of biochemical assays and detection technologies, focusing on physiologically relevant systems.
• Experience with liquid handling and automated dispensing.
• Experience analyzing large datasets with appropriate statistical methods.
• Desirable: experience running biochemical and cell-based high throughput screens in 384- and 1536-well formats, and analysis of high throughput screening data.

What will I gain?

We value ambition, professionalism, positive impact, and collaboration. We support your wellbeing, offer career and personal development, and provide high-quality tools. Our benefits page offers more details.

How do I apply?

We use an anonymized shortlisting process to promote equality, diversity, and inclusion. CVs are required but not viewed until interview invitation. Please complete the work history section of the online application. We encourage responses in your own words, sharing personal experiences, and discourage AI use to ensure fairness.