Senior Scientist, Mechanistic Cellular Pharmacology

Cancer Research UK; Babraham; On-site; GBP 50,000 - 64,000; Full time

Job summary

Cancer Research UK is seeking a Principal Scientist to lead cellular pharmacology efforts in a drug discovery setting. Based at Babraham Cambridge, you will design and run cellular assays to profile small molecules and inform dose‑prediction and efficacy.

You will shape project strategy and mentor a team of scientists in a fast‑paced environment. The role requires a strategic leader with a strong background in pharmacology, target modulation, and assay development, with opportunities to publish

Qualifications

• A BSc, MSc or PhD in biological science
• Relevant experience can be substituted for education
• Significant experience in a drug discovery environment of characterising targets and their modulation by small molecules through quantitative cellular pharmacology, including a kinetic context
• Demonstrated theoretical and practical understanding of pharmacology and drug‑target interactions
• Expertise in assay development across a range of quantitative cell‑based assay technologies, with the ability to input across multiple projects both at the lab bench and intellectually
• Significant experience of using microscopy/imaging in a quantitative pharmacology setting would be highly desirable
• Demonstrated scientific leadership skills with ability to give strategic direction
• Experience of managing the performance and development of line reports
• Credible external reputation, as evidenced through publication, presentation at key conferences, and a strong personal network

Responsibilities

• Design, develop and run cellular assays to identify and profile small molecules
• Drive project strategy and influence decision‑making within the Cellular Pharmacology team

Skills

Target characterisation

Pharmacology theory

Assay development

Microscopy/Imaging

Scientific leadership

People management

External reputation

Education

BSc, MSc or PhD in biological science

Job description

Cancer Research UK is seeking a Principal Scientist to lead cellular pharmacology efforts in a drug discovery setting. Based at Babraham Cambridge, you will design and run cellular assays to profile small molecules and inform dose‑prediction and efficacy.

You will shape project strategy and mentor a team of scientists in a fast‑paced environment. The role requires a strategic leader with a strong background in pharmacology, target modulation, and assay development, with opportunities to publish