Senior Scientist in Translational Pathology, Oncology

AstraZeneca; Cambridge; On-site; GBP 50,000 - 75,000; Full time

Job summary

A leading pharmaceutical company in Cambridge is seeking a Senior Scientist in Translational Pathology within Oncology. The role involves routine biomarker analysis, collaborating to inform clinical decisions, and utilizing advanced data technologies. Candidates should have a relevant scientific degree and experience in immunohistochemistry. This position offers an opportunity to impact innovative oncology solutions.

Qualifications

• 3 years of industry experience in a relevant field.
• Experience in biomarker assays development and validation.
• Familiarity with Good Clinical Practice.

Responsibilities

• Execute routine biomarker analysis.
• Interpret and communicate data within a matrix team.
• Inform clinical decisions for therapeutically relevant doses.

Skills

Organized

Self-motivated

Strong communication skills

Ability to troubleshoot

Education

BSc or MSc in a relevant scientific discipline with 3 years industry experience

Tools

Immunohistochemistry (brightfield or fluorescence)

Sample tracking software (BSI, SAPIO, Azenta)

Digital image analysis solutions (ImageJ, HALO, Visiopharm)

Job description

Overview

Senior Scientist in Translational Pathology, Oncology

We are seeking a Senior Scientist to join the Translational Pathology group in Oncology R&D Translational Medicine. You will be at the forefront of the evolution of translational science for a global oncology group at AstraZeneca. You will have the opportunity to impact an industry-leading portfolio of programs from early clinical development of novel therapeutics through to post-marketing opportunities that support approved targeted therapies.

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

Major Responsibilities and Accountabilities

This is a lab-based position working in a Good Clinical Practice (GCP) environment.

In this role you will be using the best available science and technology to execute routine biomarker analysis and interpret and communicate the data as part of a matrix team. Your work will inform clinical decisions for selecting therapeutically relevant doses and schedules, as well as building our understanding of key cancer pathway interactions to guide rational drug combinations. In addition, your work will help define novel mechanisms of resistance to targeted therapies by studying tumours at relapse.

Skills and experience

• BSc or MSc in a relevant scientific discipline with 3 years industry experience

• Experience in manual or automated immunohistochemistry (brightfield or fluorescence)

• Experience in microtomy

• Experience working to Good Clinical Practice

• Experience in development and validation of biomarker assays

• Experience working with human tissues and tissue-based histopathology methods

• Knowledge or experience in one or more AZ portfolio areas: tumour drivers and resistance, DNA damage response (DDR), immuno-oncology (IO) and antibody drug conjugates (ADC)

• Experience of tracking and/or managing human tissues using sample tracking software (e.g. BSI, SAPIO, Azenta, etc.)

• Highly organized and self-motivated

• Ability to work independently as well as collaboratively within a team to deliver to projects

• Strong written and oral communication skills

• Strong ability to troubleshoot and critically analyse data

Desirable/Advantageous

• Previous pharmaceutical industry experience

• Experience with digital image analysis solutions (e.g. ImageJ, HALO, Visiopharm)

• Skills in developing multiplexed immunohistochemistry or in situ hybridization (ISH) assays

• Career exposure to the pharmaceutical industry and the drug development process

AstraZeneca offers an environment where courage, curiosity, and collaboration thrive. With a vision to eliminate cancer as a cause of death, we unite cutting-edge science with the latest technology to achieve breakthroughs. Empowered at every level, our team is driven by patient outcomes, making bold decisions and taking smart risks. Join us in pioneering collaborative research with an unrivaled scientific community, working inclusively to expedite research in challenging cancers.

Ready to make an impact? Apply now and be part of a team dedicated to improving lives through innovative oncology solutions!

To find out more

Group site: AstraZeneca

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Inclusion & Diversity: Careers at AstraZeneca

Career site: Careers at AstraZeneca

Date Posted

10-set.-2025

Closing Date

24-set.-2025

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.