Senior Scientist, Immunology

Ensocell; Cambridge; On-site; GBP 45,000 - 80,000; Full time

Job summary

An innovative life science company is seeking a skilled Senior Scientist to join their Target Biology team in Cambridge. This role involves leveraging advanced single-cell technologies and a deep understanding of immunology to identify and validate novel drug targets. You will design and execute experiments using in vitro cell models, collaborate with experts in genomics and AI, and contribute to pioneering new therapies for complex diseases. Join a vibrant, interdisciplinary team that values creativity and problem-solving in a fast-paced environment, where your contributions can lead to transformational new medicines.

Qualifications

• PhD and extensive experience in immunology required.
• Hands-on experience with in vitro assays, especially with human cells.

Responsibilities

• Develop and utilize cell models to validate therapeutic targets.
• Design and conduct experiments using primary human tissue and cells.

Skills

Immunology

In vitro cell models

Flow cytometry

Experimental design

Macrophage biology

T cell biology

B cell biology

Single cell biology

Spatial biology

Next generation sequencing

Education

PhD in Immunology

Postdoctoral fellowship

Tools

Single-cell technologies

Spatial genomics

Job description

The Opportunity

Are you seeking a role with a company dedicated to unravelling the intricacies of disease pathology at the single-cell level and developing pioneering new therapies for human disease? Are you passionate about applying cutting-edge technologies and being a member of a multidisciplinary, international team?

We are in search of a self-motivated and skilled Senior Scientist to join us at our Cambridge, UK site. As an integral member of our Target Biology team, you will play a crucial role in advancing our target and therapeutics discovery initiatives. Your responsibilities will include utilizing state-of-the-art single-cell technologies, in vitro cell models, and using a deep understanding of immunology to identify and validate novel drug targets and develop mechanism-based cell assays for drug discovery.

What this role will Involve

• Leveraging your deep understanding of immunology, you will develop and utilize cell models to elucidate and validate therapeutic targets and therapeutic mechanisms of action.
• Your primary tasks will involve designing and conducting experiments to elucidate the functions of key disease cell types using primary human tissue and cells, devising and executing in vitro cell models, conducting perturbation experiments to identify high-quality drug targets and testing biologic therapeutics in complex cell models.
• You will collaborate closely with experts in single-cell and spatial genomics, antibody experts, as well as AI/ML computational scientists. Our collective aim is to pioneer innovative therapies for autoimmune, inflammatory, and fibrotic diseases.
• Ensocell continually seeks novel approaches and innovative ideas for our programs. A proactive, positive problem-solving mindset will empower you to make strategic contributions and implement your own ideas to drive Ensocell’s progress.

What we expect from you

• A PhD and extensive demonstrable experience in immunology.
• A postdoctoral fellowship and/or experience in a biotechnology/pharmaceutical setting.
• A strong record of publication in academic journals.
• Hands-on experience with developing and executing in vitro cell-based assays, especially with human cells, including flow cytometry.
• Demonstrable experience in macrophage, T cell, or B cell biology will be an advantage.
• Experience with single cell and spatial biology and next generation sequencing technologies would be an advantage.
• Proven ability to design experiments, troubleshoot, interpret and present the data.
• Collaborative, resourceful, entrepreneurial spirit, and enjoys working in a fast-paced and creative environment.

About Ensocell

Ensocell is a new venture capital-backed life science company at the intersection of single cell genomics, spatial genomics, AI, and drug discovery. Our mission is to decode the complexities of human disease biology, identify novel therapeutic intervention points, and develop precision therapeutics targeting these intervention points to create transformational new medicines. Ensocell has research teams in Cambridge, UK, and Alameda, California (USA).

At Ensocell, we foster a vital, interdisciplinary, and collaborative scientific culture. We are seeking talented, highly motivated, and intellectually curious individuals to join our team and share in our mission. Ensocell supports a welcoming and inclusive work environment that encourages openness and diversity.