Senior Scientist I - Characterisation | CMC - Oxford

ZipRecruiter; Oxford; On-site; GBP 35,000 - 55,000; Full time

Job summary

ZipRecruiter is seeking a Senior Scientist I in Oxford to characterize biotherapeutic T-cell receptor molecules. The ideal candidate will have expertise in mass spectrometry and peptide mapping. A background in biochemistry is essential, with responsibilities including developing methods and supporting drug development processes.

Qualifications

• Experience in HPLC-based peptide mapping and mass spectrometry of recombinant proteins.
• Experience in glycosylation analysis of recombinant proteins.
• Understanding of post-translational modifications.

Responsibilities

• Characterize biotherapeutic recombinant T-cell receptor molecules.
• Support drug substance and drug product impurity characterization.
• Develop and validate characterization methods.

Skills

HPLC-based peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization techniques

Assay development

Education

BSc in biochemistry or related field

MSc in biotechnology or related field

PhD in related discipline

Job description

Job Description

Senior Scientist I - Characterisation | CMC - Oxford

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company dedicated to developing transformative medicines addressing unmet patient needs in oncology, infectious diseases, and autoimmune diseases. Our R&D leaders are recognized globally as some of the biotech industry's most successful drug developers. We foster an environment that promotes interaction among great minds and drives innovation.

We focus on delivering first-in-class biological therapies, including our innovative soluble TCR platform and ImmTAX molecules, which are precision-engineered drugs harnessing the immune system to treat diseases with high unmet medical needs. At Immunocore, our employees are our greatest asset, and we value the contributions each individual brings.

Our core values—Science, Trust, Respect, Integrity, and Entrepreneurship (STRIDE)—guide our collaborative and innovative culture, enabling us to achieve our mission of transforming patients' lives through groundbreaking therapies.

We are committed to diversity and inclusion, encouraging applications from individuals of all backgrounds, regardless of characteristics protected by law.

Role Overview

The successful candidate will characterize biotherapeutic recombinant T-cell receptor molecules and related products using various protein characterization and mass spectrometry techniques. Responsibilities include developing characterization methods such as peptide mapping (LC-MS/MS) and intact mass spectrometry analysis, supporting impurity characterization, and analyzing post-translational modifications like glycosylation.

Key Responsibilities

• Supporting drug substance and drug product impurity characterization and identification
• Performing protein sequence analysis and post-translational modification identification
• Supporting process development through characterization of process intermediates
• Developing and validating characterization methods for ImmTAX and other products
• Designing biochemical characterization, stability, and comparability studies
• Contributing to study protocols and reports
• Leading investigations and proposing new experiments based on data
• Providing technical support and guidance to team members
• Mentoring colleagues and sharing scientific knowledge
• Ensuring accurate and timely laboratory record keeping
• Providing technical guidance on laboratory equipment use
• Communicating research findings effectively in meetings
• Adhering to safety policies and procedures

Person Specification

Experience & Knowledge (Essential):

• Experience in HPLC-based peptide mapping and mass spectrometry of recombinant proteins or antibodies
• Experience in glycosylation analysis of recombinant proteins or antibodies
• Extensive testing coordination of protein biomolecules
• Experience with proteins expressed in microbial and mammalian systems
• Understanding of post-translational modifications
• Experience working in a biopharmaceutical laboratory environment
• Expertise in electrophoretic, chromatographic, or mass spectrometry techniques
• Experience in assay development and stability studies
• Active contribution to diverse teams and process improvements
• Experience presenting scientific data internally and externally

Desirable:

• Further experience in glycosylation analysis, late-stage assay development, GMP principles, conference presentations, project leadership, and clinical trial material support

Education & Qualifications:

• Essential: BSc or MSc in biochemistry, biotechnology, or related field
• Desirable: PhD in related discipline