Senior Scientist (Discovery Bioscience)

Cancer Research UK; United Kingdom; Remote; GBP 42,000 - 51,000; Full time

Job summary

Cancer Research Horizons (CRH) in Cambridge is seeking a Senior Scientist in Bioscience to define and support critical path drug discovery biology for both small and large molecules. You will join the Discovery Biology team and apply your expertise to biomarker discovery and investigating disease mechanisms.

This is a lab-based role requiring deep cancer biology knowledge, hands-on drug discovery experience, and collaboration with Target Validation and Translational Biology to advance projects

Qualifications

• PhD in Cancer Biology, Cell Biology or related field with industry experience.
• Strong experimental design and scientific problem-solving skills.
• Experience with PD biomarkers and mechanism of action studies.
• Proven ability to translate biology to clinical positioning.

Responsibilities

• Design, perform and interpret gene perturbation studies in cancer models.
• Conduct phenotypic analyses including proliferation, apoptosis and colony assays.
• Identify and validate pharmacodynamic biomarkers for preclinical translation.
• Review literature and informatics databases to explore clinical positioning.

Skills

Biology & oncology

Biomarker discovery

Drug discovery

Proteomics

Flow cytometry

High-content imaging

Experimental design

Communication

Education

PhD in Cancer Biology or related

Tools

Western blot

RT-qPCR

Immunofluorescence

ELISA/MSD

Flow cytometry

Proteomics

Job description

**Senior Scientist (Discovery Biology)****Salary:** £41,700 - £51,300**Department:**Therapeutic Innovation, R&I **Reports to:**Principal Scientist **Location**: Babraham Research Campus, Cambridge (Lab Based – Low Flex) **Contract type:** Permanent position **Hours:** Full time, 35 hours per week**Closing date:** Sunday 20th September**Interview process:**2 stage interview process, initial screening call via MS Teams followed by on-site competency-based interview with presentation.**Interview Dates:**First stage between 1st – 7th October; Second stage between 14th – 16th October**At Cancer Research UK, we exist to beat cancer.**We have an exciting opportunity for a **Senior Scientist** to join us at Cancer Research Horizons (CRH) in Cambridge, for a permanent position. As a Senior Scientist in **Bioscience**, you will play a key role in defining and supporting critical path drug discovery biology for both small and large molecule therapeutics.The successful candidate will join our Discovery Biology team within our Bioscience department and apply their extensive technical expertise and knowledge to biomarker discovery, evaluating biological and disease mechanisms of action, as well as experimentally interrogating clinical positioning hypotheses.This is therefore a laboratory focused role that requires a deep scientific understanding of cancer biology, strong laboratory technical skills, and hands-on experience of drug discovery. As part of the Discovery Biology team within Bioscience, you will work closely with the Target Validation and Translational Biology teams to collaboratively address key biology across our portfolio of projects. Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that matters - impacting patients, families, and the future of science.**About Cancer Research Horizons**As the world’s biggest medical research charity, we’ve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK’s established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK’s world-class academic network, cutting edge technology platforms and clinical expertise to 1) Bring new treatments to patients faster and 2) Tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, you’ll be joining over 200 staff from both industrial and academic backgrounds, all dedicated to bringing forward the day we cure cancer and making real life impact.**What will you be doing?*** Design, perform and interpret gene perturbation studies using tool therapeutics (compounds or antibodies), gene knockdown and gene editing approaches, as well as rescue studies with over-expression systems in cancer cell lines and immune-relevant co-culture models.* Conduct and interpret phenotypic analysis in cancer cells including cell proliferation, apoptosis, and colony formation assays, including use of Incucyte analysis.* Design and execute mechanistic studies to elucidate drug-target engagement and downstream effects on biological pathways.* Identify and validate pharmacodynamic (PD) biomarkers to support preclinical-to-clinical translation using platforms including: + Western blot / capillary electrophoresis (e.g., Simple Western) + RT qPCR and RNA based signatures + Immunofluorescence for pathway activation (experience of high content imaging is desirable) + ELISA/MSD immunoassays + Flow Cytometry* Review and critically appraise oncology, relevant informatic databases, and related literature, as well as unpublished research to identify and explore novel clinical positioning opportunities and biomarkers.**What are we looking for?*** PhD (or equivalent) in Cancer Biology, Cell Biology, Molecular Biology, or a related discipline with industry experience. Candidates with a BSc or MSc (or equivalent) will also be considered if they demonstrate substantial and relevant industry experience.* Deep scientific understanding of: + Key oncology areas such as tumour signalling and metabolic pathways, genetics/ epigenetics of cancer associated gene expression, or interactions of the tumour micro-environment. + Mechanisms of drug action and drug resistance. + Pharmacology concepts.* Strong experimental design, technical expertise, and scientific problem-solving skills.* Proven track record developing and applying PD biomarkers, mechanism of action, or clinical positioning studies to support delivery of drug discovery programmes. + Experience in proteomics (including sample preparation, data review and interpretation) and/or contributing to the advancement of later-stage research programmes towards clinical development and positioning would be a bonus.* Excellent communication skills with the ability to convey complex data clearly.* Within this predominantly lab-based position can work autonomously and adapt to new challenges within a fast-paced setting.Our organisation values guide all that we do.**Bold:**Act with ambition, courage and determination **Credible:**Act with rigour and professionalism **Human**: Act to have a positive impact on people**Together:**Act inclusively and collaborativelyWe’re looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience, we’d still love to hear from you.**What will I gain?**We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.You can explore our benefits by visiting our careers web page.**How do I apply?**We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.For more information on this career opportunity please visit our website or contact us at [e-mail] more updates on our work and careers, follow us on: Linked In, Facebook, Instagram, X and YouTube.Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under-represented.We want to see every candidate performing at their best throughout the job application process, interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen. Please contact [e-mail] or **0**20 3469 8400 as soon as possible.