Senior Scientist (Assay Development)

Lightcast Discovery; Cambridge; On-site; GBP 50,000 - 75,000; Full time

Job summary

A leading company in cell analysis is seeking a Senior Scientist to join their Biology Team in Cambridge. The role involves designing innovative assays using the Lightcast platform, collaborating with various teams, and contributing to cutting-edge workflows in drug discovery. Ideal candidates will have a PhD and extensive experience in assay development.

Benefits

Pension contribution matched up to 7%

Private medical insurance

Income protection

Life insurance

Subsidized gym membership

Access to Cycle to Work scheme

Enhanced family leave policies

Qualifications

• Minimum of 5 years lab-based experience in industry.
• Demonstrable experience of cell-based assay development.
• Experience in developing single-cell functional assays.

Responsibilities

• Design and develop novel assays for various applications.
• Transform cell-based assays to picolitre-scale droplets.
• Communicate and collaborate with internal and external partners.

Skills

Assay development expertise

Communication skills

Interdisciplinary teamwork

Problem identification

Data processing skills

Education

PhD in biochemistry, cell biology, immunology or similar

Job description

Our mission is to push the boundaries of complex cell analysis. Using the Lightcast platform we are working with major pharmaceutical companies, leading academic institutes, and innovative biotechnology leaders. Together, using our next generation microfluidic platform, we are making advances towards new science, unique clinical approaches, new therapies, and innovative products.

The Lightcast platform allows precise, highly flexible, and massively parallel control of tens to hundreds of thousands of picolitre volume microdroplets using beams of light and powerful software logic. By sequentially combining droplets containing different cells, antibodies, cancer drugs, reporters and /or other reagents, we can perform complex workflows and assays at scale with a flexibility far beyond what is currently possible on any cell analysis platform.

About the role

We are looking for an experienced Senior Scientist based in Cambridge Uk to join our Biology Team. In this role, you will be involved in designing and developing novel assays for various applications using the Lightcast platform. You will have the opportunity to transform cell-based assays from traditional plate-based formats to picolitre-scale droplets, enabling new functional readouts and assay combinations at single cell resolution. Inventing and establishing novel assay formats, you will be at the forefront of developing the assays and cutting-edge workflows that present a product that makes immediate impact to our collaborators and customers in Drug Discovery. To ensure assay development at Lightcast is at the lead-edge of innovation, you will work closely with internal and external partners. Additionally, you will participate in project update meetings, horizon scanning and mind-mapping activities, contributing to the innovative and collegial culture of the team.

You will sit at the nexus of development and contribute to the commercialization, involving significant interaction with the other internal R&D teams and commercial teams at Lightcast. In a fast paced, development environment you will need a mindset adept at problem identification, together with the ability to identify and implement solutions.

As a Senior Scientist in the Biology Team, you will be expected to:

• Be a subject matter expert in the field of assay development at the protein and cellular level. Experience developing and troubleshooting assays in small volumes. Familiarity with experimental design, data acquisition and interpretation to ensure robust assay performance.
• Develop innovative experiments and deliver on platform assay options with publication-quality data; invent and optimise cell-based assays to be run on the Lightcast platform aligned with our customer needs and product development roadmap
• Keep up to date with new technologies that could be applied to the Lightcast platform as well as with the competitive landscape
• Capture and communicate any novel intellectual property that you invent during your work
• Generate SOPs,experimentalplans andresultreports at quality feeding directly into product development
• Communicate and collaborate with members of the wider company including, data scientists, software developers, engineers, chemists and commercial teams
• Prepare presentations and reports for audiences inside and outside the company, including for collaborators andclients to provide clear, effective communication of data driven results
• Work in a fast-paced environment, adapting to changing priorities and deadlines

We would expect you to have:

• PhD in a field related biochemistry, cell biology, immunology or similar field with a minimum of 5 years lab-based experience preferably in an industry setting
• Demonstrable experience of cell-based assay development, measuring secreted proteins or interactions with membrane targets
• A background in the field of antibody discovery developing assays such as AB-Binding, Blocking, Neutralizing, Internalizing, Affinity etc.
• Experience with screening of cell populations and associated data processing skills
• Excellent communication and interpersonal skills, with the ability to work in interdisciplinary teams and collaborate with external partners
• Experience on working with collaborators on complex and cutting-edge projects
• Ability to work in an agile and fast-paced environment, adapting to changing priorities and deadlines
• Experience in developing single-cell functional assays
• Assay development expetrise focussed on bead or cell-based assays in small volumes or microfluidic systems
• Prior experience in translating cell-based assays into droplet environments
• Flow cytometry assay development

We offer a generous benefits packageincluding:

• Pension contribution matched up to 7%
• Private medical insurance
• Income protection
• Life insurance
• Subsidized gym membership and weekly cross fit sessions
• Access to Cycle to Work and Technology schemes
• Enhanced family leave policies

Lightcast Discovery is committed to equal employment opportunity. Learn more about Lightcast Discovery Recruitment & Staffing Agencies:
We have agreements with our preferred suppliers and will not be adding to this list. Any resume submitted in the absence of a signed agreement will become the property of Lightcast Discovery , and will not incur a placement fee.

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