Senior Scientist - Antibody Discovery

ZipRecruiter; Maidenhead; On-site; GBP 50,000 - 90,000; Full time

Job summary

An innovative company is seeking a skilled scientist to join their Antibody Discovery team. This role focuses on utilizing advanced technologies to develop and optimize antibody therapeutics. Candidates should have a strong background in molecular biology and protein engineering, with experience in biochemical techniques and data analysis. The position offers a chance to work collaboratively with a dynamic team, contributing to groundbreaking projects that aim to improve patient outcomes. If you're passionate about science and eager to make a difference, this opportunity is perfect for you.

Qualifications

• PhD or equivalent in molecular biology with antibody knowledge.
• Experience with in vitro display libraries for protein engineering.

Responsibilities

• Discover therapeutic monoclonal antibodies to support the pipeline.
• Use yeast display for human antibody discovery and optimization.

Skills

Molecular Biology

Protein Engineering

Biochemical Techniques

Data Analysis

Communication Skills

Education

PhD in Molecular Biology

Tools

Flow Cytometry

Surface Plasmon Resonance

Bio-layer Interferometry

Next-Generation Sequencing

Job description

Job Description

Job Description

Role Overview

This is a unique opportunity to join an Antibody Discovery team working with cutting-edge technologies to help shape the delivery of next- antibody therapeutics.

This is an excellent opportunity to join a dynamic and thriving team of scientists helping to develop and validate new sequence-based and structure-based antibody design approaches. This includes elements of antibody hit identification, sequence optimization, and in silico de novo antibody design. This is a laboratory-based role where a detailed knowledge of molecular biology and microbiological methods, and a proven track record of antibody discovery or protein engineering would be a significant advantage.

Responsibilities

• Play a key role in the discovery of therapeutic monoclonal antibodies to support the pipeline and help create value for patients suffering from serious diseases.
• Use cutting-edge yeast display for the discovery and optimization of human antibodies aligned with therapeutic targets.
• Design, construct, and perform selections using bespoke synthetic display libraries to support in silico de novo antibody discovery and optimization projects.
• Prepare next- sequencing (NGS) libraries and analyze them to support antibody discovery and engineering of lead molecules.
• Work closely with computational and CADD scientists to co-develop and apply AI/Deep learning solutions and structure-based approaches to facilitate the discovery and engineering of high-quality antibody molecules.
• Contribute to the development and implementation of new methodologies in antibody display and engineering.
• Work flexibly across project teams to ensure the delivery of results against expected timelines.
• Present experimental data at cross-functional meetings.

Profile

• A PhD (or equivalent) with molecular biology and protein biochemistry knowledge, ideally within the antibody space.
• Knowledge and experience in the use of in vitro display libraries for either discovery, affinity maturation, or other protein engineering, preferably to include structure or deep sequence-guided insight.
• Demonstrable experience of biochemical techniques for the characterization of macromolecules such as flow-cytometry, surface plasmon resonance, or Bio-layer interferometry.
• Skills in informatics and other computational platforms such as molecular visualization and next- sequencing data analysis.
• Highly motivated with excellent attention to detail and critical data analysis skills.
• A trusted ability to deliver to deadlines.
• Excellent communication skills.