Senior Scientist - Analytical Development

TN United Kingdom; London; Hybrid; GBP 45,000 - 75,000; Full time

Job summary

An innovative company is seeking a Senior Scientist to join their Analytical Development Team in London. This role offers the unique opportunity to contribute to cutting-edge gene therapy projects, focusing on analytical method development and execution. As a key player in a dynamic environment, you will manage early-stage programs, collaborate with external partners, and drive the development of novel analytical techniques. If you're passionate about transforming lives through science and thrive in a fast-paced setting, this position is perfect for you.

Qualifications

• 2+ years managing analytical development projects in biotech.
• Proficiency in flow cytometry and immunoassays.

Responsibilities

• Manage analytical development plans for early-stage programs.
• Lead development and qualification of analytical methods.

Skills

Analytical Development Management

Problem-Solving Skills

Flow Cytometry

Immunoassays

Protein Detection

Single-Cell Sequencing

PCR

Primary Cell Culture

Education

BSc/MSc in a biotech-related discipline

PhD in a biotech discipline

Tools

ddPCR

Analytical Methods

Job description

Senior Scientist - Analytical Development, London

Client: Orchard Therapeutics

Location: London, United Kingdom

Job Category: Other

EU work permit required: Yes

Job Reference: 45e1c3cbf127

Job Views: 1

Posted: 08.05.2025

Expiry Date: 22.06.2025

Job Description

Location: London, Hybrid

Reporting to: Director, Advanced Analytics

Job Summary

Orchard Therapeutics is a global gene therapy leader dedicated to transforming the lives of people affected by rare diseases through innovative, curative cell and gene therapies. Orchard has its global headquarters in London and U.S. headquarters in Boston, and is a wholly owned subsidiary of Kyowa Kirin, a Japan-based Global Specialty Pharmaceutical Company.

As a key member of the Global Analytical Development Team, this role will support analytical development for early phase programs and execute method development at Orchard. Responsibilities include experiment design, setting acceptance criteria, experiment execution, and data analysis of various analytical methods. This is an exciting opportunity to join an international company focused on transforming lives through innovative gene therapies.

Key Responsibilities

1. Manage the analytical development plan of early-stage programs as a key member of a CMC team.
2. Serve as the single point of contact for projects with external parties such as CDMOs, CROs, or vendors.
3. Lead the development and qualification of analytical methods for cell and gene therapy programs.
4. Perform and develop analytical methods including protein and cell-based tools, LVV analytics, immunoassays, and ddPCR.
5. Assess novel equipment and methodologies.
6. Write SOPs to support activities, including tech transfer to internal departments or external partners.
7. Maintain accurate lab records and prepare final reports to support internal analytical activities.
8. Perform other activities as assigned.

Requirements

Experience & Knowledge

• Minimum 2 years managing analytical development projects.
• Understanding of process development needs for LVV and gene-modified cell products.
• Knowledge of FDA, EMA, GMP, WHO, and ICH regulatory standards is advantageous.
• Experience in assay development with strong problem-solving skills.
• Ability to drive analytical method development with internal and external resources.
• Proficiency in techniques such as flow cytometry, enzymatic activity assessment, immunoassays, and protein detection. Knowledge of single-cell sequencing, PCR, and primary cell culture is required.
• Experience with autologous cell therapy and lentiviral vector assessment is desirable.
• Understanding of tech transfer processes for analytical methods to GMP labs is a plus.
• Excellent interpersonal, organizational, and communication skills.
• Ability to operate in a fast-paced, multidisciplinary environment.

Education

• BSc/MSc in a biotech-related discipline.
• PhD in a biotech discipline with 5+ years postdoctoral experience is preferred.