Senior Research Scientist in Genetic Manipulation

Francis Crick Institute Ltd; London; On-site; GBP 125,000 - 150,000; Full time

Job summary

A leading biomedical research facility in London is seeking a Senior Research Scientist in Genetic Manipulation to contribute to pioneering research in genetics. The ideal candidate will have extensive experience and a strong track record in genome engineering and CRISPR techniques. This full-time role offers generous benefits, including a pension scheme and health support services.

Benefits

Generous annual leave

Pension scheme with employer contributions

Health & well-being support

Discounted gym memberships

Childcare support allowance

Qualifications

• PhD or MSc/BSc with a proven track record and 5 years’ experience in a relevant field.
• Considerable relevant experience with a track record of achievement in genome engineering.
• Knowledge and practical experience of CRISPR/Cas techniques.

Responsibilities

• Design and plan cloning strategies for genetically modified alleles.
• Support and troubleshoot core molecular biology and cell culture techniques.
• Plan and coordinate the in vivo gene delivery pipeline.

Skills

Genome engineering

Molecular biology

Mammalian cell culture

CRISPR/Cas design

Collaborative teamwork

Education

PhD or MSc/BSc in relevant field

Tools

DNA analysis software

Genome browsers

Job description

Senior Research Scientist in Genetic Manipulation page is loaded

Senior Research Scientist in Genetic Manipulation

Apply locations London time type Full time posted on Posted Yesterday job requisition id R2363

Salary for this Role:

From £45,795 with benefits, subject to skills and experience

Job Title:

Senior Research Scientist in Genetic Manipulation

Reports to:

Graham Duddy

Closing Date:

26/Aug/2025 23.59 GMT

Job Description:

Senior Research Scientist in Genetic Manipulation

Details of the role:

Working pattern: Monday – Friday. t his is a full-time, permanent position on Crick terms and conditions

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

The Genetic Modification Services (GeMS) provide a breadth of specialist skills and resources for the design, creation, production, storage and use of genetically altered animals, germplasms and cell lines together with ancillary techniques.

The services that GeMS currently compromises are: molecular biology, micromanipulation, surgical expertise, cryopreservation of rodent and aquatics germplasms, assisted Reproductive techniques such as IVF, AI, ICSI, Rederivation of live and frozen imports & exports to and from the Crick, and murine stem cell culture.

As the GeMS Senior Research Scientist (SRS), you will play a pivotal role in developing new animal models and leading projects from start to finish. An in-depth understanding of molecular biology, cell culture, genetic modification, and mouse genetics is required. You will also ensure that the 3Rs principles for in vivo research—replacement, reduction, and refinement—underpin all work undertaken.

This could be the perfect opportunity for you to join the team if you have a PhD. or MSc/BSc with a proven track record and five years’ of experience in a relevant field, including in-depth knowledge and demonstrable skills genome modification, gene targeting, and the use of the CRISPR-Cas systems.

What you will be doing

As a BRF GeMS Senior Research Scientist at the Crick, you will:

• Design and plan complex cloning strategies, genotyping strategies and the generation of molecular reagents, for the production and validation of new genetically modified alleles, predominantly using CRISPR-based genetic manipulation.
• Use, implement, support and troubleshoot the execution of core molecular biology and cell culture techniques and implement novel methodologies within the group to improve production efficiency and accuracy.
• Support the Senior Manager in the design and implementation for the creation of new animal models. Take responsibility not only for a subset of GeMS projects but also take a wider, proactive view across the entire GeMS portfolio.
• Plan and co-ordinate the in vivo gene delivery pipeline, for the direct manipulation of the mouse zygote, and the gene targeting pipeline for manipulation of mouse embryonic stem cells. Engage in out of hours cell culture work rota.
• Trouble shoot problematic experiments across the GeMS portfolio.

Please see the full job description here.

About you

You will have:

• PhD or MSc/BSc with a proven track record and 5 years’ experience in a relevant field.
• Possess considerable relevant experience with a track record of achievement and demonstrable skill in genome engineering, molecular biology and mammalian cell culture.
• Exhibit knowledge, understanding and practical experience of CRISPR/CAS design and associated techniques.
• Experienced in the use genome browsers, DNA analysis software and CRISPR Cas guide on/off target specificity software.
• Commitment to continued professional development (CPD).
• Experience of contributing effectively to the work of a team with a flexible and collaborative approach.

About Working at the Crick

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!

• We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.

• We areopen. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.

• We arecollegial. We show respect for one another, work cooperatively and support the wider community.

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post) please email: [e-mail]

Find out more about life at the Crick.

Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed.

We reserve the right to withdraw this advert at any given time due to the number of applications received.

What will you receive?

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:

• Visas: Applicants for this role will be eligible for sponsorship to work in the UK

• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.

• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.

• Health & Well-being:

• 24/7 GP consultation services.

• Occupational health services and mental health support programs.

• Eye care vouchers and discounted healthcare plans.

• Work-Life Balance:

• Back-up care for dependents.

• Childcare support allowance.

• Annual leave purchase options.
• Crick Networks offering diverse groups’ support, community and inclusive social events.

• Perks:

• Discounted gym memberships, bike-to-work scheme, and shopping discounts.

• Subsidised on-site restaurant and social spaces for team interaction.