Senior Research Scientist II – Target Identification & Validation

Immunocore; Oxford; On-site; GBP 45,000 - 80,000; Full time

Job summary

Join a pioneering biotechnology company as a Senior Research Scientist II in Target Identification & Validation. This role offers the chance to contribute to groundbreaking research in AML and solid cancers, collaborating with leading experts and advancing innovative therapies. With a focus on scientific excellence and teamwork, you will lead efforts in target validation, develop novel assays, and mentor junior scientists. This is an exciting opportunity to be part of a mission-driven organization that values diversity and fosters an inclusive workplace, where your contributions can make a significant impact in transforming patient lives.

Qualifications

• In-depth knowledge of AML biology and disease models.
• Strong experience with AML primary cells and assays.

Responsibilities

• Lead wet-lab efforts for AML target validation and discovery.
• Develop novel assays to enhance TI&V workflows.

Skills

AML disease biology

LSC/HSC isolation

Colony forming assays

Immune-phenotyping

Excellent communication skills

Teamwork

Flexibility and willingness to learn

Education

PhD in a relevant field

Tools

Multiplex Flow Cytometry

CRISPR

Job description

Job Details: Senior Research Scientist II – Target Identification & Validation

Vacancy Name: Senior Research Scientist II – Target Identification & Validation

Vacancy No: VN512

Employment Type: Permanent

Location of role: Oxford, UK

Department: Research

Key Responsibilities

1. Go-to person for the wet-lab questions and dataset building, related to validation of AML targets.
2. Contribute to target discovery and validation of additional targets (solid cancers, autoimmune).
3. Independently act as a representative of TI/TV group at two AML programme teams, supporting programme leader/co-leaders, and contributing proactively to discussions, planning and hypotheses testing, in collaboration with Pipeline Biology and Drug Discovery/PE teams.
4. TI/TV representative at AML oncology working group, deepening AML expertise in IMCR, bringing forward independent scientific ideas for the in-house and external development of AML models.
5. Based on the long-term experience in academic AML field, advance IMCR pipeline AML programmes, by reaching out to suitable KOLs in the field, building novel collaborations and testing novel scientific hypotheses.
6. Represent TI/TV leader at PTMs, working groups and other cross-functional meetings and act as interface between Target Identification & Validation and other Research groups.
7. Develop and optimise novel assays to improve TI&V workflows (e.g. Colony forming assay LSC/HSC, Multiplex Flow cytometry, CRISPR etc).
8. Contribute to research publications, conference attendance, training processes.
9. Supervise and mentor junior team members.

Experience & Knowledge

Essential

1. In-depth knowledge of AML disease biology, optimal disease models and KOLs.
2. Strong experience in dealing with AML primary cells, LSC/HSC isolation, colony forming assays and immune-phenotyping.
3. Excellent Communication skills - Ensuring information and learnings are passed on correctly and in a timely way throughout the organization.
4. Shown flexibility and willingness to learn new techniques and practices.
5. Track record in scientific excellence as demonstrated by project/technology development.
6. Teamwork - Working cooperatively as part of a team.

Desirable

1. Understanding of the drug discovery process post-target nomination.

About the Company

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.