Senior R&D Scientist

Hurdle; United Kingdom; Remote; GBP 45,000 - 70,000; Full time

Job summary

Hurdle is seeking a Senior R&D Scientist in Bioinformatics to enhance biological insights from omic data. The role involves producing R&D deliverables, developing bioinformatic pipelines, and collaborating with commercial teams to support partnerships. This position offers the opportunity to work in a dynamic environment focused on advancing diagnostics and biomarker development.

Benefits

Fully remote working

Private health insurance - Vitality

Enhanced paternity leave

Pension provided through Nest

Qualifications

• PhD in relevant field and/or 4+ years of research experience.
• 2+ years in healthcare or life sciences industry.

Responsibilities

• Produce R&D deliverables for partnerships and internal pipeline.
• Develop, QC, and maintain bioinformatic pipelines.
• Present deliverables to R&D partners.

Skills

DNA methylation arrays

Next-generation sequencing

R

Python

Bash

AWS

Statistical modelling

Machine learning

Project management

Communication

Education

PhD in Epigenetics, Bioinformatics, Computational Biology, or related field

Job description

Hurdle.bio is revolutionising the biotechnology landscape by democratising access to novel diagnostics through cutting-edge bio-infrastructure. Since 2017, we've processed over 3 million tests and partnered with global healthcare leaders to provide comprehensive diagnostic solutions and multi-omics biomarker services.

We're on a mission to transform how companies and consumers access biological insights. With our end-to-end platform spanning sample collection, lab testing, logistics, and digital interfaces, we're making advanced diagnostics more accessible than ever.

The role:

The Senior R&D Scientist , Bioinformatics is responsible for producing R&D deliverables within agreed timeframes and budget. This includes maximising the biological insights we obtain from different sources of omic data, ultimately leading to the development of novel biomarker assets within the Chronomics bio-infrastructure that serve our partners.

Duties/Responsibilities:

• Produce R&D deliverables (analysis, reports, code, …) for Chronomics R&D partnerships (inc. pharma and life sciences partnerships) and internal pipeline within agreed timeframes.
• Work closely with the commercial team to present deliverables to R&D partners, support new R&D commercial proposals and increase revenue through this channel.
• Develop, QC and maintain our bioinformatic pipelines, working closely with the engineering department.
• Identify and access the latest data assets for biomarker R&D purposes.
• Write papers and present work at scientific conferences.
• Work with other Hurdle functions on Science deliverables as required, including supporting the commercial and operations teams on our bioinformatic and genomics products.

Other ad hoc duties:

• Bring expertise in other omics and multi-omics integration.
• Bring expertise in Nanopore sequencing analysis and biomarker discovery.
• Bring on-board the latest tools or software for the relevant tasks (e.g. epigenetic imputation, graph alignments, mendelian randomization, …).
• Be able to build rapid prototypes to test out concepts quickly and cheaply
• Write secure, scalable, documented code with automated tests.
• Follow dev best practices.
• Document all systems.

Required Skills/Abilities:

• Deep knowledge and expertise in DNA methylation arrays and next-generation sequencing (including downstream biological annotation tools).
• Good programming skills in common bioinformatics tools such as R, Python, bash, and ideally workflow languages (e.g. Nextflow).
• Expertise working in a cloud computing environment (AWS).
• Excellent knowledge of statistical modelling and machine learning
• Experience working with large and complex datasets including multi-omics
• Excellent project management skills and task-oriented.
• Strong attention to detail.
• Strong written and verbal communication skills (internal and external).
• Experience communicating research outputs to scientific and broader audiences (papers, conferences, …).
• Driven, independent and with a can-do attitude.
• Quantitative and analytical mindset.
• Flexibility and adaptability.
• Thrives in a fast paced and agile environment.
• Able to multitask and work cross functionally.
• Creative and out-of-the-box thinking.

Additional Preferred Skills/Abilities:

• Experience working with wet-lab scientists.
• Previous experience with a large human cohort (e.g. UK Biobank).
• Previous experience with Electronic Health Records.
• Familiar with complex technologies (proteomics, mass spectrometry, microfluidics, imaging, …).
• Good understanding of common molecular biology technologies (PCR, chromatography, ELISA).
• Familiar with regulatory frameworks for IVDs.
• Passionate about preventative healthcare.

Education and Experience:

• PhD in Epigenetics, Bioinformatics, Computational Biology, Statistical Genetics or related field and/or 4+ years of research experience in computational biology environments.
• 2+ years of experience working in the healthcare or life sciences industry.

Physical Requirements:

• Prolonged periods of sitting at a desk and working on a computer.

Other duties

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

• Take what you need annual leave
• Fully remote working (UK)
• Private health insurance - Vitality
• Enhanced paternity leave
• Pension provided through Nest

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

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