Senior Principal Toxicology Scientist

TN United Kingdom; Cambridge; Hybrid; GBP 60,000 - 100,000; Full time

Job description

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Senior Principal Toxicology Scientist, Cambridge

Client:

Location: Cambridge, United Kingdom

Job Category: Other

EU work permit required: Yes

Job Reference: 46f60f3500d1

Job Views: 8

Posted: 26.04.2025

Expiry Date: 10.06.2025

Job Description:

Reporting to the VP DMPK and Safety, you will be an experienced, highly motivated toxicologist, joining a small team responsible for leading safety studies and strategy in support of Benevolent’s drug discovery and development portfolio. You will provide clear guidance based on your experience to Principal and Senior Scientists and influence strategy and project direction across pipeline phases through strong interpersonal skills and well-presented rationale.

With hybrid working from home and our London or Cambridge offices, you will be a core member of drug discovery project teams, acting as the safety point of contact to progress programs from early discovery to the clinic.

Responsibilities:

1. Lead toxicologist role within the DMPK and Safety department to define safety and toxicology strategies from TID to the clinic.
2. Lead, perform, and review target safety assessments, providing mitigation strategies using data from toxicological assays, bespoke approaches, and in silico tools to understand mechanisms. Develop target de-risking strategies for new projects.
3. Ensure toxicology screening strategies are applied to predict, assess, and mitigate safety risks across the portfolio.
4. Develop and review study protocols and reports with CROs, ensuring timely and quality completion of studies.
5. Analyze, interpret, and present toxicology data to project teams, updating risk assessments and providing mitigation strategies based on emerging data.
6. Provide guidance to Principal and Senior Scientists based on experience.
7. Review in vitro toxicology studies and oversee CROs providing nonclinical study services.

We are looking for:

• BSc/MSc/PhD in toxicology, pharmacology, biochemistry, or a related discipline
• 10+ years’ experience in toxicology, with knowledge across various disease areas
• Experience in leading, managing, and developing staff
• Hands-on experience assessing target safety and devising screening strategies
• Understanding of in vitro to in vivo translation and implications for human safety
• Strong interpersonal, communication, collaboration, and organizational skills
• Experience as a safety lead in multifunctional project teams
• Track record in drug discovery and development, including late-stage regulatory safety packages (IB, CTA, Pre-IND)
• Experience with in silico and in vitro safety assessment, including using platforms like Lhasa Ltd NEXUS