Senior Principal Toxicology Scientist

BenevolentAI; Cambridge; Hybrid; GBP 70,000 - 100,000; Full time

Job summary

A leading biotechnology company is seeking a Senior Principal Toxicology Scientist based in Cambridge, UK. This role involves leading safety strategies in drug discovery, guiding project teams, and applying expertise in toxicology and pharmacology to ensure safety from early discovery to clinical trials. Candidates should have extensive experience and a strong educational background in relevant fields.

Qualifications

• 10+ years of experience in toxicology with broad knowledge across disease areas.
• Experience in leading and developing staff.
• Hands-on assessment experience of target safety prior to portfolio entry.

Responsibilities

• Lead toxicologist within the DMPK and Safety department defining safety strategies.
• Perform target safety assessments and develop mitigation strategies.
• Analyze, interpret, and present toxicology data to project teams.

Skills

Interpersonal skills

Communication

Collaboration

Organizational skills

Leadership

Education

BSc/MSc/PhD in toxicology, pharmacology, biochemistry, or related fields

Tools

NEXUS platform

Job description

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Senior Principal Toxicology Scientist, Cambridge

Location: Cambridge, United Kingdom

Job Category: Other

EU work permit required: Yes

Job Reference: 46f60f3500d1

Job Views: 5

Posted: 02.06.2025

Expiry Date: 17.07.2025

Job Description:

Reporting to the VP DMPK and Safety, you will be an experienced, highly motivated toxicologist, joining a small team responsible for leading safety studies and strategy in support of Benevolent’s drug discovery and development portfolio. You will provide clear guidance based on prior experience to Principal and Senior Scientists, influencing strategy and project direction across pipeline phases through strong interpersonal skills and well-presented rationale.

With hybrid working from home and our London or Cambridge offices, you will be a core member of drug discovery project teams, acting as the safety point of contact to progress programs from early discovery to the clinic.

Responsibilities

• Lead toxicologist within the DMPK and Safety department to define safety and toxicology strategies from TID to the clinic.
• Perform and review target safety assessments, develop mitigation strategies using data from toxicological assays, bespoke approaches, and in silico tools to understand mechanisms, and develop target de-risking strategies for new projects.
• Ensure appropriate toxicology screening strategies are applied to predict, assess, and mitigate safety risks.
• Develop and review study protocols and reports with CROs, ensuring quality and timely completion.
• Analyze, interpret, and present toxicology data to project teams, updating risk assessments and providing mitigation strategies based on emerging data.
• Provide guidance to Principal and Senior Scientists based on experience.
• Review in vitro toxicology studies and oversee CRO services for nonclinical studies.

We are looking for:

• BSc/MSc/PhD in toxicology, pharmacology, biochemistry, or related fields.
• 10+ years of experience in toxicology, with broad knowledge across disease areas.
• Experience in leading and developing staff.
• Hands-on assessment experience of target safety prior to portfolio entry and designing screening strategies.
• Understanding of in vitro to in vivo translation of toxicities and implications for human safety.
• Strong interpersonal, communication, collaboration, and organizational skills.
• Experience as safety lead in multifunctional project teams.
• Track record in drug discovery and development programs, including late-stage regulatory safety packages supporting IB, CTA, Pre-IND.
• Experience with in silico and in vitro safety assessments, including the Lhasa Ltd NEXUS platform.