Senior Principal, Statistical Programmer

Novartis AG; Greater London; Hybrid; GBP 49,000 - 91,000; Full time

Benefits offered by this job

Hybrid work option

Job summary

Novartis AG in London, UK is seeking a Senior Principal Statistical Programmer to lead complex programming strategies across high-impact studies and programs, partnering with cross-functional teams to deliver regulatory-ready outputs.

You will coordinate activities of programmers, drive standardization, review data structures and CRFs, and ensure quality control and reproducibility of analyses and CSRs. Hybrid work is supported.

Qualifications

• BS/MS degree in statistics, computer science, mathematics, data science, life science or equivalent relevant degree
• Extensive experience in Statistical programming languages (R, SAS, Python) and Git-based version control
• Advanced experience in contributing to statistical analysis plans and technical programming specifications
• Advanced knowledge of CDISC data structures and industry regulatory requirements
• Strong communication and collaboration skills across global teams

Responsibilities

• Lead SP activities for one or multiple trials or as Lead/Program Programmer for a program or indication
• Coordinate internal/external programmers and propose strategies at study/program level
• Act as functional manager for associates, providing supervision and guidance to programmers
• Build and maintain relationships with cross-functional teams; summarize status of deliverables
• Review eCRF and data structures; ensure standardization for CSR production
• Ensure quality control, reproducibility, and code quality across complex workflows

Skills

R

SAS

Python

Git

Education

BS/MS degree in statistics or related field

Tools

Git-based version control

R packages (Tidyverse)

R Shiny

Job description

Salary Range: £49,140.00 - £91,260.00

Job Description Summary

#LI-Hybrid

Location: London, UK Remote working can be considered

This role is based in London, UK. Novartis is unable to offer relocation support for this role. Please only apply if this location is accessible for you.

Step into a pivotal role where your expertise shapes the future of clinical development. As a Senior Principal Statistical Programmer, you will lead complex programming strategies across high-impact studies and programs, partnering with cross-functional teams to deliver high-quality, regulatory-ready outputs. This is your opportunity to influence innovation, drive modern programming practices, and make a tangible difference in bringing life-changing medicines to patients faster.

Job Description

Key responsibilities:

• Lead SP activities as Trial Programmer for one or multiple trial(s) or as a Lead/ Program Programmer for a program or an indication.
• May coordinate activities of internal/ external programmers. Make SP decisions and propose strategies at study, program or indication/ disease level.
• May act as functional manager of associates including providing supervision and guidance to these programmers on operational / functional expertise and processes.
• Build and maintain effective working relationship with cross-functional teams, able to summarize and discuss status of deliverables and critical programming aspects (timelines, scope, resource plan), e.g. as SP representative in study- or program-level team.
• Review eCRF, data structures, and ensure program-level standardization for effective pooling and efficient case record tabulation (CRT) production.
• Comply with company, department and industry standards (e.g. CDISC) and processes, assess and clarify additional programming requirements, review, develop and influence programming specifications as part of the analysis plans (incl. program-level strategies).
• Provide and implement statistical programming solutions; ensure knowledge sharing. Act as programming expert in problem-solving aspects.
• Ensure timely and quality development and validation of datasets and outputs for clinical study reports (CSRs), regulatory submissions/interactions, safety reports, publications, post-marketing activities or exploratory analyses (as required) in the assigned drug development studies/program. Understand Git-based version control workflows and their role in supporting collaborative, traceable, and reproducible programming activities.
• Responsible for quality control and inspection readiness of all assigned statistical programming deliverables as well as accuracy and reliability of statistical analysis results. Establishes robust expectations and frameworks for reproducibility, documentation, and code quality across complex workflows; leads refinement of templates, standards, and governance.
• Maintain up-to-date advanced knowledge of statistical programming languages (e.g. R, SAS, ) as well as industry requirements (e.g. CDISC, eCTD, Define.xml), act as an expert for advanced analysis, reporting, automation and enterprise-scale workflow optimization, and drive adoption of reusable solutions and modern approaches across studies or programs

Essential Requirements:

• BS/MS degree in statistics, computer science, mathematics, data science, life science or equivalent relevant degree
• Extensive experience and deep expertise in Statistical programming languages (e.g., R, SAS, or Python) to drive standardization across studies or programs and effectively adopt R packages (e.g. Tidyverse), R Shiny Applications, AI-enabled tools etc. to support data visualization, version control (e.g. Git-based), and reproducible workflows.
• Advanced experience in contributing to statistical analysis plans and/or constructing technical programming specifications
• Advanced knowledge of industry standards including CDISC data structures as well as a solid understanding of the development and use of standard programs
• Good understanding of regulatory requirements relevant to Statistical Programming (e.g. GCP, study procedures)
• Proven communications and negotiation skills, ability to work well with others globally and influence
• Experience as Trial/Lead/Program Programmer for several studies or project-level activities, including coordination of team of internal or external programmers on a given study/program, ability to transfer own knowledge to others

Benefits & Rewards

At Novartis, we're committed to reimagining medicine together - and rewarding the people who make it happen.

Expected Annual Base Salary Range for role: £49,140.00 - £91,260.00 Annual

The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.

In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.

The rewards o